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Identification of Pore-forming Subunit of P-type Calcium Channels: an Antisense Study on Rat Cerebellar Purkinje Cells in Culture
March 1997
March 1997
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Abstract
Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN)
against alpha1A, reduced the whole-cell P-type calcium channel current relative to
mismatch ODN treated controls (p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell
calcium current in mismatch and antisense treated cells by 70 +/- 4 and 19 +/- 3%,
respectively.