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      Pulsatile Distention and Vascular Collagen Synthesis in the Rabbit

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      Journal of Vascular Research

      S. Karger AG

      Pulsatile flow, Collagen, Elastin, Stretch

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          In rabbits, collagen synthesis was studied in five different regions of the vascular tree which are subjected to different degrees of pulsatile distention, i.e., cyclic stretching, and mean pressure. The vessels with greatest pulsatile distention had the highest specific activity of hydroxyproline in collagen after incubation with <sup>14</sup>C-proline and the inferior vena cava with low pressure and negligible pulsatile distention had the lowest specific activity. The findings suggest a link between mechanical stretching and cellular metabolic function and have significance as to the relationship of pulsatile flow to normal vascular and organ physiology.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 17
          : 4
          : 216-220
          Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pa.
          158251 Blood Vessels 1980;17:216–220
          © 1980 S. Karger AG, Basel

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          Pages: 5
          Research Paper


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