Pulsatile Distention and Vascular Collagen Synthesis in the Rabbit

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Abstract

In rabbits, collagen synthesis was studied in five different regions of the vascular tree which are subjected to different degrees of pulsatile distention, i.e., cyclic stretching, and mean pressure. The vessels with greatest pulsatile distention had the highest specific activity of hydroxyproline in collagen after incubation with <sup>14</sup>C-proline and the inferior vena cava with low pressure and negligible pulsatile distention had the lowest specific activity. The findings suggest a link between mechanical stretching and cellular metabolic function and have significance as to the relationship of pulsatile flow to normal vascular and organ physiology.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1980

Publication date (Print): 1980

Publication date (Electronic): 19 September 2008

Volume: 17

Issue: 4

Pages: 216-220

Affiliations

Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pa.

Article

Publisher ID: 158251 Other ID: Blood Vessels 1980;17:216–220

DOI: 10.1159/000158251

SO-VID: 91077354-6b2e-4246-9787-ec997c9c2c4c

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 20 August 1979

Date accepted : 06 December 1979

Page count

Pages: 5

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