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      Enfermedad hepática por depósito de grasa Translated title: Hepatic disease due to fat deposit

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          Abstract

          La enfermedad hepática por depósito de grasa adquiere cada vez una importancia mayor como entidad y, al mismo tiempo, como factor de riesgo aislado o asociado al síndrome metabólico. Con el objetivo de actualizar algunos aspectos relacionados con esta hepatopatía, tales como su actual nomenclatura y nuevo enfoque etiopatogénico, se efectuó la presente revisión bibliográfica desde una perspectiva clínica, la que incluye datos elementales sobre la fisiopatología y las características de presentación de la entidad, así como las principales armas utilizadas en su diagnóstico, control o terapéutica. Se demuestra, además, que la visión sobre el tema ha cambiado en los últimos años y constituye fuente de investigación en múltiples grupos prestigiosos por las particularidades de su evolución

          Translated abstract

          The hepatic disease due to fat deposit acquires greater importance as entity and, at the same time, as isolated or associated risk factor to the metabolic syndrome. With the objective of updating some aspects related to this hepatopathy, such as its current nomenclature and new etiopathogenic approach; the present literature review was carried out from a clinical perspective, which includes elementary data on the pathophysiology and the presentation characteristics of the entity, as well as the main tools used in its diagnosis, control or therapy. It is also demonstrated, that the vision on the topic has changed in the last years and it constitutes an investigation source in multiple noted groups due to the particularities of its clinical course

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          Most cited references29

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          Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

          New England Journal of Medicine, 362(18), 1675-1685
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            The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.

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              Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults.

              Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, and its worldwide prevalence continues to increase with the growing obesity epidemic. This study assesses the epidemiology of NAFLD in adults based on clinical literature published over the past 30 years. To review epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults based on clinical literature published over the past 30 years. An in-depth search of PubMed (1980-2010) was based on five search terms: 'non-alcoholic fatty liver disease' OR 'non-alcoholic steatohepatitis' OR 'fatty liver' OR 'steatosis' AND 'incidence' [MeSH Terms] OR 'prevalence' [MeSH Terms] OR 'natural history'. Studies of paediatric cohorts were excluded. Articles were categorised by topic and summarised, noting generalisations concerning their content. Four study categories included NAFLD incidence, prevalence, risk factors and natural history. Studies related to NAFLD prevalence and incidence indicate that the diagnosis is heterogeneous and relies on a variety of assessment tools, including liver biopsy, radiological tests such as ultrasonography, and blood testing such as liver enzymes. The prevalence of NAFLD is highest in populations with pre-existing metabolic conditions such as obesity and type II diabetes. Many studies investigating the natural history of NAFLD verify the progression from NASH to advanced fibrosis and hepatocellular carcinoma. Non-alcoholic fatty liver disease is the most common cause of elevated liver enzymes. Within the NAFLD spectrum, only NASH progresses to cirrhosis and hepatocellular carcinoma. With the growing epidemic of obesity, the prevalence and impact of NAFLD continues to increase, making NASH potentially the most common cause of advanced liver disease in coming decades. © 2011 Blackwell Publishing Ltd.
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                Author and article information

                Journal
                san
                MEDISAN
                MEDISAN
                Centro Provincial de Información de Ciencias Médicas (Santiago de Cuba, , Cuba )
                1029-3019
                July 2015
                : 19
                : 7
                : 886-896
                Affiliations
                [01] Santiago de Cuba orgnameHospital Provincial Docente Clinicoquirúrgico Saturnino Lora Torres Cuba
                Article
                S1029-30192015000700009 S1029-3019(15)01900709
                9117e627-753c-4fd6-9ccf-36f2b75bbade

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 08 June 2015
                : 10 June 2015
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 30, Pages: 11
                Product

                SciELO Cuba

                Categories
                ARTÍCULOS DE REVISIÓN

                esteatosis hepática,lipidogram,non-alcoholic fatty liver,hepatic steatosis,lipidograma,hígado graso no alcohólico

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