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      Oral multispecies biofilm development and the key role of cell-cell distance.

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          Abstract

          Growth of oral bacteria in situ requires adhesion to a surface because the constant flow of host secretions thwarts the ability of planktonic cells to grow before they are swallowed. Therefore, oral bacteria evolved to form biofilms on hard tooth surfaces and on soft epithelial tissues, which often contain multiple bacterial species. Because these biofilms are easy to study, they have become the paradigm of multispecies biofilms. In this Review we describe the factors involved in the formation of these biofilms, including the initial adherence to the oral tissues and teeth, cooperation between bacterial species in the biofilm, signalling between the bacteria and its role in pathogenesis, and the transfer of DNA between bacteria. In all these aspects distance between cells of different species is integral for oral biofilm growth.

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          Author and article information

          Journal
          Nat Rev Microbiol
          Nature reviews. Microbiology
          Springer Science and Business Media LLC
          1740-1534
          1740-1526
          Jul 2010
          : 8
          : 7
          Affiliations
          [1 ] National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA. pkolenbrander@dir.nidcr.nih.gov
          Article
          nrmicro2381
          10.1038/nrmicro2381
          20514044
          912d4e18-b87f-4a2f-890d-faa2cf97c1f0
          History

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