Electrophysiological Evidence for a Key Control Function of the Medial Preoptic Area in the Regulation of Prolactin Secretion in Cycling, Pregnant and Lactating Rats

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Female rats were chronically fitted with stainless steel electrodes in the medial preoptic area (MPOA), together with a chronic atrial blood sampling/blood transfusion catheter. The surgery did not affect cyclicity, pregnancy or lactation. Twenty-five minutes of bilateral electrical stimulation (100-Hz voltage pulses, 0.2 ms width, 10 s on/5 s off) of the MPOA significantly reduced the magnitude of the proestrous and estrous afternoon levels of prolactin (Prl) in cycling rats, the nocturnal and diurnal levels of Prl in pregnant rats as well as Prl secretion during suckling in lactating rats. These data demonstrate that the MPO exerts dominant inhibitory control over all known surges of Prl secretion in female rats and may be considered as ‘antisurge key control center’ for Prl secretion. A functional role of the sexually dimorphic nucleus in the control of Prl secretion is suggested.

Related collections

Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1990

Publication date (Print): 1990

Publication date (Electronic): 03 April 2008

Volume: 51

Issue: 2

Pages: 162-167

Affiliations

Department of Animal Physiology, Agricutural University, Wageningen, The Netherlands

Article

Publisher ID: 125332 Other ID: Neuroendocrinology 1990;51:162–167

DOI: 10.1159/000125332

PubMed ID: 2106097

SO-VID: 91340751-e8a8-4835-a561-1979bf013b1d

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 03 March 1989

Date accepted : 13 June 1989

Page count

Pages: 6

Comments

Comment on this article

scite_