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      The distinctive biology of cancer in adolescents and young adults.

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          Abstract

          One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-1768
          1474-175X
          Apr 2008
          : 8
          : 4
          Affiliations
          [1 ] St Charles Medical Center, 2500 NE Neff Road, Bend, Oregon 97701, USA. ableyer@scmc.org
          Article
          nrc2349
          10.1038/nrc2349
          18354417
          913b7b32-d495-4c94-be9f-f5a6ed03754d
          History

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