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      Transcatheter mitral valve repair for primary mitral regurgitation

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          Abstract

          The landscape of transcatheter mitral valve repair devices continues to expand, with many technologies undergoing investigation in patients with primary mitral regurgitation (MR). Transcatheter edge-to-edge repair (TEER) of the mitral valve is currently approved for management of patients with severe primary MR who are deemed to be high risk surgical candidates. The current review will focus on an integrative clinical and echocardiographic approach to guide patient selection, intra-procedural imaging guidance, and post procedural follow up in patients undergoing TEER. This review will also highlight future directions in transcatheter repair techniques of the mitral valve.

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          Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance.

          William Zoghbi, David Adams, Robert Bonow … (2017)
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            Burden of valvular heart diseases: a population-based study.

            Vuyisile T Nkomo, Julius M Gardin, Thomas N Skelton … (2006)
            Valvular heart diseases are not usually regarded as a major public-health problem. Our aim was to assess their prevalence and effect on overall survival in the general population. We pooled population-based studies to obtain data for 11 911 randomly selected adults from the general population who had been assessed prospectively with echocardiography. We also analysed data from a community study of 16 501 adults who had been assessed by clinically indicated echocardiography. In the general population group, moderate or severe valve disease was identified in 615 adults. There was no difference in the frequency of such diseases between men and women (p=0.90). Prevalence increased with age, from 0.7% (95% CI 0.5-1.0) in 18-44 year olds to 13.3% (11.7-15.0) in the 75 years and older group (p<0.0001). The national prevalence of valve disease, corrected for age and sex distribution from the US 2000 population, is 2.5% (2.2-2.7). In the community group, valve disease was diagnosed in 1505 (1.8% adjusted) adults and frequency increased considerably with age, from 0.3% (0.2-0.3) of the 18-44 year olds to 11.7% (11.0-12.5) of those aged 75 years and older, but was diagnosed less often in women than in men (odds ratio 0.90, 0.81-1.01; p=0.07). The adjusted mortality risk ratio associated with valve disease was 1.36 (1.15-1.62; p=0.0005) in the population and 1.75 (1.61-1.90; p<0.0001) in the community. Moderate or severe valvular diseases are notably common in this population and increase with age. In the community, women are less often diagnosed than are men, which could indicate an important imbalance in view of the associated lower survival. Valve diseases thus represent an important public-health problem.
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              2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

              Catherine M Otto, Rick A. Nishimura, Robert Bonow … (2020)
              This executive summary of the valvular heart disease guideline provides recommendations for clinicians to diagnose and manage valvular heart disease as well as supporting documentation to encourage their use. A comprehensive literature search was conducted from January 1, 2010, to March 1, 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, Cochrane, Agency for Healthcare Research and Quality Reports, and other selected database relevant to this guideline. Many recommendations from the earlier valvular heart disease guidelines have been updated with new evidence and provides newer options for diagnosis and treatment of valvular heart disease. This summary includes only the recommendations from the full guideline which focus on diagnostic work-up, the timing and choice of surgical and catheter interventions, and recommendations for medical therapy. The reader is referred to the full guideline for graphical flow charts, text, and tables with additional details about the rationale for and implementation of each recommendation, and the evidence tables detailing the data considered in developing these guidelines.
              Article 0 comments Cited 517 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Nadeen N. Faza
                Christos Mihos: Role: Academic Editor
                Francesco Nappi: Role: Academic Editor
                Cristiano Spadaccio: Role: Academic Editor
                Massimo Chello: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Rev Cardiovasc Med
                Journal ID (publisher-id): RCM
                Title: Reviews in Cardiovascular Medicine
                Publisher: IMR Press
                ISSN (Print): 2153-8174
                ISSN (Electronic): 1530-6550
                Publication date (Electronic): 26 March 2022
                Publication date Collection: April 2022
                Volume: 23
                Issue: 4
                Electronic Location Identifier: 116
                Affiliations
                [1] 1Department of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX 77030, USA
                Author notes
                *Correspondence: nnfaza@ 123456houstonmethodist.org (Nadeen N. Faza)
                Article
                Publisher ID: S1530-6550(22)00440-9
                DOI: 10.31083/j.rcm2304116
                PMC ID: 11273645
                PubMed ID: 39076234
                SO-VID: 913d65d3-6d88-4985-9fea-8880445a964e
                Copyright © Copyright: © 2022 The Author(s). Published by IMR Press.
                License:

                This is an open access article under the CC BY 4.0 license.

                History
                Date received : 15 November 2021
                Date revision received : 27 December 2021
                Date accepted : 30 December 2021
                Categories
                Subject: Review

                Keywords: mitral regurgitation,mitraclip,transcatheter mitral valve repair
                Data availability:
                Keywords: mitral regurgitation, mitraclip, transcatheter mitral valve repair

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