7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Quantitative ultrasound radiofrequency data analysis for the assessment of hepatic steatosis using the controlled attenuation parameter as a reference standard

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          This study was aimed to investigate the value of quantitative ultrasound (US) parameters from radiofrequency (RF) data analysis for assessing hepatic steatosis, using controlled attenuation parameter (CAP)-based steatosis grades as the reference standard.

          Methods

          We analyzed 243 participants with both B-mode liver US with RF data acquisition and CAP measurements. On B-mode US images, hepatic steatosis was visually scored (0/1/2/3, none/mild/moderate/severe), and the hepatorenal index (HRI) was calculated. From the RF data analysis, the tissue scatter-distribution imaging parameter (TSI-p) and tissue attenuation imaging parameter (TAI-p) of the liver parenchyma were measured. US parameters were correlated with CAP-based steatosis grades (S0/1/2/3, none/mild/moderate/severe) and their diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Multivariate linear regression analysis was performed to identify determinants of TSI-p and TAI-p.

          Results

          Participants were classified as having S0 (n=152), S1 (n=54), S2 (n=14), and S3 (n=23) on CAP measurements. TSI-p and TAI-p were significantly correlated with steatosis grades (ρ =0.593 and ρ=-0.617, P<0.001 for both). For predicting ≥S1, ≥S2, and S3, the areas under the ROC curves (AUCs) of TSI-p were 0.827/0.914/0.917; TAI-p, 0.844/0.914/0.909; visual scores, 0.659/0.778/0.794; and HRI, 0.629/0.751/0.759, respectively. TSI-p and TAI-p had significantly higher AUCs than did visual scores or HRI for ≥S1 or ≥S2 (P≤0.003). In the multivariate analysis, the transient elastography-based fibrosis grade (P=0.034) and steatosis grade (P<0.001) were independent determinants of TSI-p, while steatosis grade (P<0.001) was an independent determinant of TAI-p.

          Conclusion

          TSI-p and TAI-p derived from US RF data may be useful for detecting hepatic steatosis and assessing its severity.

          Related collections

          Most cited references40

          • Record: found
          • Abstract: found
          • Article: not found

          A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.

          Intraclass correlation coefficient (ICC) is a widely used reliability index in test-retest, intrarater, and interrater reliability analyses. This article introduces the basic concept of ICC in the content of reliability analysis.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.

                Bookmark

                Author and article information

                Journal
                Ultrasonography
                Ultrasonography
                USG
                Ultrasonography
                Korean Society of Ultrasound in Medicine
                2288-5919
                2288-5943
                January 2021
                9 May 2020
                : 40
                : 1
                : 136-146
                Affiliations
                [1 ]Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
                [2 ]Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
                [3 ]Department of Radiology, Konkuk University School of Medicine, Seoul, Korea
                [4 ]Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
                Author notes
                Correspondence to: Ijin Joo, MD, Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea Tel. +82-2-2072-3107 Fax. +82-2-743-6385 E-mail: hijijin@ 123456gmail.com
                Author information
                http://orcid.org/0000-0002-8991-3986
                http://orcid.org/0000-0002-1341-4072
                http://orcid.org/0000-0001-6853-8577
                http://orcid.org/0000-0002-2938-6635
                http://orcid.org/0000-0002-5265-8723
                http://orcid.org/0000-0003-0869-269X
                http://orcid.org/0000-0003-0780-7985
                http://orcid.org/0000-0003-0561-8777
                Article
                usg-20042
                10.14366/usg.20042
                7758108
                32654442
                913f2b96-f943-4a8d-9837-2b83426d747c
                Copyright © 2021 Korean Society of Ultrasound in Medicine (KSUM)

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 19 March 2020
                : 8 May 2020
                : 9 May 2020
                Categories
                Original Article

                ultrasonography,liver,fatty liver
                ultrasonography, liver, fatty liver

                Comments

                Comment on this article