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      Protective immunity against malaria liver stage after vaccination with live parasites

      Parasite

      EDP Sciences

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          Abstract

          Despite nearly 100 years of research and control efforts, malaria remains one of the most important infectious diseases. An efficient vaccine would be a powerful to tool to reduce mortality and morbidity. Experimentally, induction of sterile immunity in humans after vaccination with attenuated sporozoites has been obtained. This observation has spurred the search for subunit vaccines that aim to reproduce this protection. As yet none of the current candidate subunit vaccines achieved complete protection reproducibly. This failure coupled to the recent advent of genetically modified Plasmodium parasites has led to a renewed interest in the use of live parasites for vaccination against malaria pre-erythrocytic stages. In this article, we review and discuss the recent developments in this field.

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          Author and article information

          Journal
          Parasite
          Parasite
          EDP Sciences
          1252-607X
          1776-1042
          September 2008
          September 2008
          : 15
          : 3
          : 379-383
          Article
          10.1051/parasite/2008153379
          18814710
          © 2008

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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          Self URI (journal page): http://www.parasite-journal.org/

          Parasitology, Life sciences

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