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      Treatment of Life-Threatening Lithium Toxicity with High-Volume Continuous Venovenous Hemofiltration

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          There is still debate as to the preferred extracorporeal treatment modality for severe lithium intoxication. Because lithium is readily diffusable, intermittent hemodialysis is usually performed. However, this bares the risk of a post-dialysis rebound concentration and, in the case of severe lithium poisoning collapse, aggravation of hemodynamic instability. Because of the relatively slow but continuous solute removal, continuous renal replacement therapy (CRRT) may be advantageous. We report the first case in the literature of severe lithium intoxication treated effectively with high-volume continuous venovenous hemofiltration (HV-CVVH). Results compared favorably to other forms of CRRT in terms of lithium clearance. Ease of implementation, the excellent tolerability and the superior lithium clearance without rebound phenomenon may make HV-CVVH the preferred treatment modality for severe lithium poisoning.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          October 2000
          15 November 2000
          : 20
          : 5
          : 408-411
          aDepartments of Medicine and bClinical Pharmacy, Albert Schweitzer Hospital, Location Amstelwijck, Dordrecht, The Netherlands
          13627 Am J Nephrol 2000;20:408–411
          © 2000 S. Karger AG, Basel

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