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      Antiviral activities of tragacanthin polysaccharides on Punta Toro virus infections in mice.

      1 , , , , ,
      Chemotherapy
      S. Karger AG

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          Abstract

          Tragacanthin polysaccharides from Astragalus brachycentrus (AV208) and Astragalus echidnaeformis (AV212) plants, which are devoid of in vitro antiviral activity, were evaluated in a mouse model of Punta Toro virus (PTV) infection. The PTV (a phlebovirus member of the Bunyaviridae family of viruses) is a model for studying the treatment of Rift Valley fever and hantavirus infections. Single intraperitoneal treatments with 12.5-200 mg/kg/day doses of AV212 given 24 h before or 4 and 24 h after virus inoculation protected the majority of mice from mortality. Single treatments with AV208 were ineffective when given 24 h before the virus challenge; however, protection was afforded when treatments were administered at 4 and 24 h following virus inoculation. In a follow-up study, AV208 treatments of 1.6-50 mg/kg/day given 24 h subsequent to virus exposure caused reductions in mortality, liver infection scores, liver and spleen virus titers, and serum transaminases. The polysaccharides did not activate lymphocytes or natural killer cells, nor was interferon induced in treated mice. However, mice pretreated with fumed silica (a macrophage poison) and infected with the PTV were not protected by subsequent administration of AV208 or AV212 at 50 mg/kg, providing evidence that activation of peritoneal macrophages by the polysaccharides affords protection to infected animals. These compounds should be considered for the potential treatment of significant human infections induced by bunyaviruses and hantaviruses.

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          Author and article information

          Journal
          Chemotherapy
          Chemotherapy
          S. Karger AG
          0009-3157
          0009-3157
          July 1 1996
          : 42
          : 4
          Affiliations
          [1 ] Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322-5600, USA.
          Article
          10.1159/000239457
          8804797
          9167321c-5f32-4eeb-8712-dcd6c9419be7
          History

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