+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: not found

      Cortical excitability in neuroleptic-naive first-episode schizophrenic patients.

      Schizophrenia Research
      Adult, Case-Control Studies, Differential Threshold, physiology, radiation effects, Dose-Response Relationship, Radiation, Electric Stimulation, methods, Evoked Potentials, Motor, Female, Humans, Magnetics, Male, Motor Cortex, physiopathology, Muscles, Neural Conduction, drug effects, Neural Inhibition, Schizophrenia, Time Factors

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Transcranial magnetic stimulation (TMS) provides an intriguing in vivo method to investigate motor cortex excitability in men. This offers new insights into the neurophysiological basis of neuropsychiatric diseases. Earlier TMS studies in patients with schizophrenia revealed inconsistent results, probably due to major confounding variables like state of medication and stage of illness. To control for these effects, we studied two TMS paradigms in 21 drug-naive first-episode schizophrenic patients and 21 age- and sex-matched healthy controls. The patient group demonstrated a significant lower resting motor threshold as compared with healthy controls, whereas TMS paradigms of intracortical inhibition and intracortical facilitation failed to show significant differences between patients and controls. This pattern of TMS parameters is similar to that obtained in healthy volunteers investigated under increasing doses of ketamine, a central acting drug known to produce psychosis-like effects. In agreement with recent results of functional imaging, our neurophysiological findings suggest that drug-induced and naturally occurring psychosis may share a common pathway, which may base on dysfunctional glutamatergic mechanisms.

          Related collections

          Author and article information


          Comment on this article