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      Increased factor XIa levels in patients with a first acute myocardial infarction: the introduction of a new thrombin generation based factor XIa assay.

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          Abstract

          One of the contributing mechanisms in acute myocardial infarction (AMI) is plasma hypercoagulability. Recently, it was suggested that factor XI activation might play a role in atherothrombosis. To quantify factor XIa plasma levels, we developed a new thrombin generation based assay and hypothesized that in AMI patients factor XIa levels are increased during the acute thrombotic event.

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          Affiliations
          [1 ] Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, The Netherlands. Electronic address: rinske.loeffen@maastrichtuniversity.nl.
          [2 ] Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, The Netherlands.
          [3 ] Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
          [4 ] Department for Cardiovascular Medicine, Division of Cardiology, University of Münster, Münster, Germany.
          [5 ] Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
          Journal
          Thromb. Res.
          Thrombosis research
          Elsevier BV
          1879-2472
          0049-3848
          Dec 2014
          : 134
          : 6
          S0049-3848(14)00500-3
          10.1016/j.thromres.2014.09.015
          25288467

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