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      Dietary inflammatory potential and risk of mortality in metabolically healthy and unhealthy phenotypes among overweight and obese adults

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          Abstract

          This study was designed to investigate the association between the dietary inflammatory index (DII ® ) scores, metabolic phenotypes, and risk of mortality risk in overweight/obese individuals from a representative sample of the U.S. population. Data from 3733 overweight/obese adults (BMI≥25kg/m 2 ) aged 20–90 years from the National Health and Nutrition Examination Survey III, 1988–1994 were analyzed; these participants were followed for mortality through December 31, 2011. DII scores were computed based on baseline dietary intake using 24-hour dietary recalls. Metabolically unhealthy status was defined as having 2 or more of these metabolic abnormalities: high glucose, insulin resistance, elevated blood pressure, triglycerides, C-reactive protein levels, or low high-density lipoprotein-cholesterol values. In metabolically unhealthy overweight/obese (MUO) individuals, DII score was associated with increased risk of all-cause mortality (HR Tertile 3 vs Tertile 1 1.44; 95% CI 1.11–1.86 P trend =0.008; HR 1SD increase 1.08; 95% CI 0.99–1.18). Additionally, a stronger association with cardiovascular mortality was observed (HR T3 vs T1 3.29; 95% CI 2.01–5.37 P trend <0.001; HR 1SD increase 1.40; 95% CI 1.18–1.66), after adjusting for potential confounders. Furthermore, when analyses were restricted to obese individuals (BMI≥30 kg/m 2 ), the association was more pronounced, especially for cardiovascular mortality (HR T3 vs T1 5.55; 95% CI 2.11–14.57 P trend =0.006; HR 1SD increase 1.74; 95% CI 1.21–2.50). No association was observed between DII score and risk of mortality in individuals with metabolically healthy overweight/obese (MHO) phenotype, or for cancer mortality in either MHO or MUO phenotype. A pro-inflammatory diet appears to increase risk of all-cause and cardiovascular mortality in the MUO phenotype, but not among the MHO phenotype.

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          Author and article information

          Journal
          Clinical Nutrition
          Clinical Nutrition
          Elsevier BV
          02615614
          April 2018
          April 2018
          Article
          10.1016/j.clnu.2018.04.002
          6389430
          29705061
          917e469c-7a91-4cd6-bef7-7027489dc532
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/


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