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      Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

      , ,
      Cell Host & Microbe
      Elsevier BV

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          Abstract

          The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease. Deciphering the complex equilibrium between these pathways will facilitate a better understanding of the pathogenesis of human diseases and open therapeutic opportunities.

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          Author and article information

          Journal
          Cell Host & Microbe
          Cell Host & Microbe
          Elsevier BV
          19313128
          June 2018
          June 2018
          : 23
          : 6
          : 716-724
          Article
          10.1016/j.chom.2018.05.003
          29902437
          91920e22-c21e-452a-b474-5f43e5c431b4
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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