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      The pulsed high magnetic field facility and scientific research at Wuhan National High Magnetic Field Center

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          Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects ☆

          Nucleic acids carry the building plans of living systems. As such, they can be exploited to make cells produce a desired protein, or to shut down the expression of endogenous genes or even to repair defective genes. Hence, nucleic acids are unique substances for research and therapy. To exploit their potential, they need to be delivered into cells which can be a challenging task in many respects. During the last decade, nanomagnetic methods for delivering and targeting nucleic acids have been developed, methods which are often referred to as magnetofection. In this review we summarize the progress and achievements in this field of research. We discuss magnetic formulations of vectors for nucleic acid delivery and their characterization, mechanisms of magnetofection, and the application of magnetofection in viral and nonviral nucleic acid delivery in cell culture and in animal models. We summarize results that have been obtained with using magnetofection in basic research and in preclinical animal models. Finally, we describe some of our recent work and end with some conclusions and perspectives.
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            Magnetic targeting for site-specific drug delivery: applications and clinical potential.

            Magnetic vehicles are very attractive for delivery of therapeutic agents as they can be targeted to specific locations in the body through the application of a magnetic field gradient. The magnetic localization of a therapeutic agent results in the concentration of the therapy at the target site consequently reducing or eliminating the systemic drug side effects. The aim of this review is to provide an update on the progress made in the development of the magnetic targeting technique addressing characteristics of the magnetic carriers and limitations of the current targeting magnet systems. This review discusses fundamental requirements for the optimal formulation of the magnetic carrier, current applications and potentially new approaches for the magnetically mediated, site-specific localization of therapeutic agents, including drugs, genes and cells. More efficient targeting magnetic systems in combination with prolonged circulation lifespan and carriers' surface recognition properties will improve the targeting efficiency of magnetic nanocarriers and enhance therapeutic agent availability at the molecular site of agent action. The main future magnetic targeting applications were categorized emphasizing the most promising directions and possible strategies for improving the magnetic targeting technique.
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              Dirac vs. Weyl in topological insulators: Adler-Bell-Jackiw anomaly in transport phenomena

              Dirac metals (gapless semi-conductors) are believed to turn into Weyl metals when perturbations, which break either time reversal symmetry or inversion symmetry, are employed. However, no experimental evidence has been reported for the existence of Weyl fermions in three dimensions. Applying magnetic fields near the topological phase transition from a topological insulator to a band insulator in Bi1-xSbx, we observe not only the weak anti-localization phenomenon in magnetoconductivity near zero magnetic fields (B < 0.4 T) but also its upturn above 0.4 T only for E // B. This incompatible coexistence between weak anti-localization and negative magnetoresistivity is attributed to the Adler-Bell-Jackiw anomaly (topological E B term) in the presence of weak anti-localization corrections.
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                Author and article information

                Journal
                Matter and Radiation at Extremes
                Matter and Radiation at Extremes
                Elsevier BV
                2468080X
                November 2017
                November 2017
                : 2
                : 6
                : 278-286
                Article
                10.1016/j.mre.2017.10.002
                91bf0cc8-d74b-4834-9ad4-0f4c5292dde1
                © 2017

                https://www.elsevier.com/tdm/userlicense/1.0/

                http://creativecommons.org/licenses/by-nc-nd/4.0/

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