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      Photoreceptor Transplants Increase Host Cone Survival in the Retinal Degeneration ( rd) Mouse

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          Abstract

          Retinal transplants offer a potentially interesting approach to treating human retinal degenerations, but so far little quantitative data are available on possible beneficial effects. We isolated photoreceptor layers from normal-sighted mice and grafted them into the subretinal space of retinal degeneration ( rd) mice lacking rod photoreceptors. At 2 weeks after surgery, the numbers of residual host cone photoreceptors outside the graft zone were quantified following specific labelling. Examination of operated retinas revealed highly significantly greater numbers of surviving cones (mean of 38% more at 2 weeks) within the central field compared to sham-operated paired control retinas (p < 0.01). These are the first quantified data indicating a trophic effect of transplanted photoreceptors upon host cone cells. As cone cells are responsible for high acuity and colour vision, such data could have important implications not only for eventual therapeutic approaches to human retinal degenerations but also to understanding underlying interactions between retinal photoreceptors.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          978-3-8055-6577-6
          978-3-318-05530-6
          0030-3747
          1423-0259
          1997
          1997
          11 December 2009
          : 29
          : 5
          : 290-297
          Affiliations
          aLaboratoire de Physiopathologie Rétinienne, INSERM CJF 92/02-ULP, Clinique Ophtalmologique, Centre Hospitalier et Universitaire, Strasbourg, France; bSensory Neuroscience Laboratory, Central Institute for the Deaf, and cDepartment of Ophthalmology and Visual Science, Washington University Medical School, St. Louis, Mo., USA
          Article
          268027 Ophthalmic Res 1997;29:290–297
          10.1159/000268027
          9323720
          © 1997 S. Karger AG, Basel

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          Page count
          Pages: 8
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