Contributors
Ezio Bonifacio:
ORCID: http://orcid.org/0000-0002-8704-4713
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SupervisionRole: Writing – original draftRole: Writing – review &
editing
Andreas Beyerlein: Role: Formal analysisRole: Writing – original draftRole: Writing – review & editing
Markus Hippich:
ORCID: http://orcid.org/0000-0001-6253-2596
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: Writing – review
& editing
Christiane Winkler: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
Project administrationRole: Writing – review & editing
Kendra Vehik:
ORCID: http://orcid.org/0000-0001-6243-6772
Role: Data curationRole: Formal analysisRole: Writing – review & editing
Michael N. Weedon: Role: Data curationRole: Formal analysisRole: InvestigationRole: Writing – review
& editing
Michael Laimighofer:
ORCID: http://orcid.org/0000-0003-1708-0302
Role: Data curationRole: Formal analysisRole: Writing – review & editing
Andrew T. Hattersley: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Jan Krumsiek: Role: Data curationRole: Formal analysisRole: Writing – review & editing
Brigitte I. Frohnert:
ORCID: http://orcid.org/0000-0002-6636-4048
Role: Data curationRole: Writing – review & editing
Andrea K. Steck: Role: Data curationRole: Writing – review & editing
William A. Hagopian:
ORCID: http://orcid.org/0000-0003-2979-0475
Role: Data curationRole: InvestigationRole: Project administrationRole: Writing –
review & editing
Jeffrey P. Krischer: Role: Data curationRole: Project administrationRole: Writing – review & editing
Åke Lernmark:
ORCID: http://orcid.org/0000-0003-1735-0499
Role: Data curationRole: Funding acquisitionRole: InvestigationRole: Writing – review
& editing
Marian J. Rewers: Role: Data curationRole: Funding acquisitionRole: InvestigationRole: Writing – review
& editing
Jin-Xiong She: Role: Data curationRole: Funding acquisitionRole: Writing – review & editing
Jorma Toppari: Role: Data curationRole: Funding acquisitionRole: InvestigationRole: Writing – review
& editing
Beena Akolkar: Role: Funding acquisitionRole: InvestigationRole: Project administrationRole: Writing
– review & editing
Richard A. Oram: Role: Data curationRole: Formal analysisRole: InvestigationRole: Writing – review
& editing
Stephen S. Rich: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Anette-G. Ziegler:
ORCID: http://orcid.org/0000-0002-6290-5548
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: ResourcesRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
Ronald C. W. Ma: Role: Academic Editor
Journal
Journal ID (nlm-ta): PLoS Med
Journal ID (iso-abbrev): PLoS Med
Journal ID (publisher-id): plos
Journal ID (pmc): plosmed
Title:
PLoS Medicine
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1549-1277
ISSN
(Electronic):
1549-1676
Publication date
(Electronic):
3
April
2018
Publication date Collection:
April
2018
Volume: 15
Issue: 4
Electronic Location Identifier: e1002548
Affiliations
[1
]
DFG–Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität
Dresden, Dresden, Germany
[2
]
Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany
[3
]
Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar,
Munich, Germany
[4
]
Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany
[5
]
Health Informatics Institute, Morsani College of Medicine, University of South Florida,
Tampa, Florida, United States of America
[6
]
Institute of Biomedical and Clinical Science, University of Exeter Medical School,
Exeter, United Kingdom
[7
]
Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany
[8
]
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora,
Colorado, United States of America
[9
]
Pacific Northwest Diabetes Research Institute, Seattle, Washington, United States
of America
[10
]
Department of Clinical Sciences, Clinical Research Centre, Skåne University Hospital,
Lund University, Malmo, Sweden
[11
]
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta
University, Augusta, Georgia, United States of America
[12
]
Department of Pediatrics, Turku University Hospital, Turku, Finland
[13
]
Department of Physiology, University of Turku, Turku, Finland
[14
]
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes
of Health, Bethesda, Maryland, United States of America
[15
]
Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada
[16
]
National Institute for Health Research, Exeter Clinical Research Facility, Exeter,
United Kingdom
[17
]
Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia,
United States of America
Chinese University of Hong Kong, CHINA
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: A patent has been applied for (EP17178396/LU100334) with the
title "Method the risk to develop type 1 diabetes" by Helmholtz Zentrum München Deutsches
Forschungszentrum für Gesundheit und Umwelt (GmbH). EB, AGZ, CW and JK are one of
the inventors. The patent includes the genetic score that is examined in the manuscript.
RAO has a personal funding from Diabetes UK to study the biology of Type 1 diabetes
(this includes a research grant to work on genetic risk scores in Type 1 diabetes).
RAO has a UK Medical Research Council confidence in concept grant to turn a type 1
diabetes genetic risk score into a diagnostic test for clinical practice. AB, MH,
KV, MNW, ML, ATH, BIF, AKS, WAH, JPK, AL, MJR, JXS, JT, BA, SSR have declared that
no other competing interests exist.
¶ Membership of the TEDDY Study Group is provided in the Acknowledgments.
Author information
Article
Publisher ID:
PMEDICINE-D-17-04068
DOI: 10.1371/journal.pmed.1002548
PMC ID: 5882115
PubMed ID: 29614081
SO-VID: 91c8702c-79bb-411b-a481-5a2d20eb8f4a
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
History
Date
received
: 14
November
2017
Date
accepted
: 1
March
2018
Page count
Figures: 5,
Tables: 0,
Pages: 18
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100000062, National Institute of Diabetes and Digestive and Kidney Diseases;
Award ID: U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01
DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836,
UC4 DK95300, UC4 DK100238, UC4 DK106955, and Contract No. HHSN267200700014C
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Funded by: funder-id http://dx.doi.org/10.13039/100000071, National Institute of Child Health and Human Development;
Funded by: National Institute of Environmental Health Sciences
Funded by: funder-id http://dx.doi.org/10.13039/100000901, Juvenile Diabetes Research Foundation International;
Funded by: funder-id http://dx.doi.org/10.13039/100000030, Centers for Disease Control and Prevention;
Funded by: NIH/NCATS Clinical and Translational Science Awards
Award ID: UL1 TR000064
Funded by: funder-id http://dx.doi.org/10.13039/100010174, University of Colorado;
Award ID: UL1 TR001082
Funded by: iMed–the Helmholtz Initiative on Personalized Medicine
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6290-5548
Anette-G. Ziegler
Funded by: DFG Research Center and Cluster of Excellence - Center for Regenerative Therapies
Dresden
Award ID: FZ 111
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8704-4713
Ezio Bonifacio
This work was supported by U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01
DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865,
UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, and Contract No.
HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National
Institute of Child Health and Human Development (NICHD), National Institute of Environmental
Health Sciences (NIEHS), Juvenile Diabetes Research Foundation (JDRF), and Centers
for Disease Control and Prevention (CDC). This work was supported in part by NIH/NCATS
Clinical and Translational Science Awards to the University of Florida (UL1 TR000064)
and the University of Colorado (UL1 TR001082), and by iMed–the Helmholtz Initiative
on Personalized Medicine. EB is supported by the DFG Research Center and Cluster of
Excellence - Center for Regenerative Therapies Dresden (FZ 111). BA from the NIDDK
was involved in the design and conduct of the study as well as the review of the manuscript,
and approval to submit the manuscript. Otherwise, the funders had no role in study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Medicine and Health Sciences
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Autoantibodies
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Autoantibodies
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Autoantibodies
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Autoantibodies
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Autoantibodies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Human Genetics
Subject:
People and Places
Subject:
Population Groupings
Subject:
Age Groups
Subject:
Children
Subject:
People and Places
Subject:
Population Groupings
Subject:
Families
Subject:
Children
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genetics of Disease
Subject:
Genetic Predisposition
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genetic Loci
Subject:
People and Places
Subject:
Population Groupings
Subject:
Age Groups
Subject:
Children
Subject:
Infants
Subject:
People and Places
Subject:
Population Groupings
Subject:
Families
Subject:
Children
Subject:
Infants
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Heredity
Subject:
Genetic Mapping
Subject:
Variant Genotypes
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