Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

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Abstract

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.

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Journal

Title: Journal of Alzheimer's Disease

Abbreviated Title: JAD

Publisher: IOS Press

ISSN (Electronic): 18758908

ISSN (Print): 13872877

Publication date Created: June 20 2013

Publication date (Print): June 20 2013

Volume: 34

Issue: 2

Pages: 457-468

Affiliations

[1 ]Siemens Molecular Imaging, Inc., Culver City, CA, USA

[2 ]Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, CA, USA

[3 ]Shankle Clinic Memory and Cognitive Disorders Program, Hoag Neurosciences Institute, Newport Beach, CA, USA

Article

DOI: 10.3233/JAD-122059

PubMed ID: 23234879

SO-VID: 91ccd2aa-f13f-4f64-9a69-076ac352051d

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