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      Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

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          Abstract

          Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.

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          Author and article information

          Journal
          Journal of Alzheimer's Disease
          JAD
          IOS Press
          18758908
          13872877
          June 20 2013
          June 20 2013
          : 34
          : 2
          : 457-468
          Affiliations
          [1 ]Siemens Molecular Imaging, Inc., Culver City, CA, USA
          [2 ]Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, CA, USA
          [3 ]Shankle Clinic Memory and Cognitive Disorders Program, Hoag Neurosciences Institute, Newport Beach, CA, USA
          Article
          10.3233/JAD-122059
          23234879
          91ccd2aa-f13f-4f64-9a69-076ac352051d
          © 2013

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