Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles,
are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed
a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807,
which may be useful for imaging Alzheimer's disease and other tauopathies. Here in,
we describe the first human brain images with [F-18]-T807.