There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Fructus Mume pill (FMP) has been used as a folk remedy for gastrointestinal diseases
in China over thousands of years. FMP was approved for the treatment of gastrointestinal
diseases in 2001 by the State Food and Drug Administration (SFDA) of China. Although
FMP had significant efficacy for treatment of the patients with inflammatory bowel
disease (IBD) in the clinic, the mechanism of action is still unclear.
In the present study, the effects and possible mechanism of FMP on colitis induced
by 2,4,6-trinitrobenzene sulfonic acid (TNBS) were investigated.
Fifty-four SD rats were divided into six groups. Nine rats for each group from three
independent experiments were investigated for the effects of FMP.
FMP protected against diarrhea, colon weight increase, colonic accretion, ulceration
and myeloperoxidase (MPO) activity elevation. The effects of FMP on recovery of colonic
damage and restoration of the normal structures of colorectums were superior to dexamethasone
(DEX). FMP promoted the restoration of abnormal cytokine secretion after TNBS treatment.
FMP was effective in restoring the balance of intestinal bacteria population from
the imbalance of G(+)/G(-) in rats with colitis.
The results indicated that FMP is effective in treatment of colitis in an experimental
rat model. The possible mechanisms may be through down-regulation of Th1-polarized
immune response and opsonic effect of intestinal commensal bacteria in this model