Michelle Y.-H. Lee:
ORCID: https://orcid.org/0000-0002-5722-1109
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: ValidationRole: VisualizationRole: Writing – original draft
Amit A. Upadhyay:
ORCID: https://orcid.org/0000-0002-0952-4164
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Writing – original
draft
Hasse Walum: Role: ConceptualizationRole: Formal analysisRole: Writing – original draft
Chi N. Chan:
ORCID: https://orcid.org/0000-0001-9106-9481
Role: Formal analysisRole: InvestigationRole: MethodologyRole: Validation
Reem A. Dawoud:
ORCID: https://orcid.org/0000-0003-4857-505X
Role: MethodologyRole: Project administration
Christine Grech:
ORCID: https://orcid.org/0000-0002-0737-2048
Role: Methodology
Justin L. Harper:
ORCID: https://orcid.org/0000-0002-6948-3501
Role: Methodology
Kirti A. Karunakaran:
ORCID: https://orcid.org/0000-0002-3310-7686
Role: Methodology
Sydney A. Nelson: Role: Investigation
Ernestine A. Mahar:
ORCID: https://orcid.org/0000-0002-6740-0688
Role: InvestigationRole: Project administration
Kyndal L. Goss:
ORCID: https://orcid.org/0000-0002-0863-9998
Role: Formal analysis
Diane G. Carnathan: Role: Investigation
Barbara Cervasi: Role: InvestigationRole: Methodology
Kiran Gill: Role: InvestigationRole: Methodology
Gregory K. Tharp:
ORCID: https://orcid.org/0000-0003-3075-755X
Role: Data curationRole: Formal analysis
Elizabeth R. Wonderlich:
ORCID: https://orcid.org/0000-0002-0773-6569
Role: InvestigationRole: Methodology
Vijayakumar Velu:
ORCID: https://orcid.org/0000-0003-4238-1924
Role: Formal analysisRole: Investigation
Simon M. Barratt-Boyes: Role: Resources
Mirko Paiardini: Role: Resources
Guido Silvestri: Role: Resources
Jacob D. Estes:
ORCID: https://orcid.org/0000-0002-9652-6394
Role: Formal analysisRole: Resources
Steven E. Bosinger:
ORCID: https://orcid.org/0000-0002-2116-5061
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: Project
administrationRole: ResourcesRole: SupervisionRole: Writing – original draftRole:
Writing – review & editing
Daniel C. Douek: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
28
June
2021
Publication date Collection:
June
2021
Volume: 17
Issue: 6
Electronic Location Identifier: e1009674
Affiliations
[1
]
Division of Microbiology & Immunology, Yerkes National Primate Research Center, Atlanta,
Georgia, United States of America
[2
]
Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton,
Oregon, United States of America
[3
]
Flow Cytometry Core, Emory Vaccine Center, Emory University, Atlanta, Georgia, United
States of America
[4
]
Yerkes NHP Genomics Core Laboratory, Yerkes National Primate Research Center, Atlanta,
Georgia, United States of America
[5
]
Southern Research, Frederick, Maryland, United States of America
[6
]
Department of Pathology and Laboratory Medicine, School of Medicine, Emory University,
Atlanta, Georgia, United States of America
[7
]
Department of Infectious Diseases and Microbiology, Graduate School of Public Health,
University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
[8
]
Oregon National Primate Research Center, Oregon Health & Science University, Beaverton,
Oregon, United States of America
Vaccine Research Center, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PPATHOGENS-D-20-02491
DOI: 10.1371/journal.ppat.1009674
PMC ID: 8270445
PubMed ID: 34181694
SO-VID: 91eac7d3-6c89-484f-bf39-8a211f2c43fa
Copyright © © 2021 Lee et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: R01 AI136990
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2116-5061
Steven E. Bosinger
Funded by:
funder-id http://dx.doi.org/10.13039/100000052, NIH Office of the Director;
Award ID: R24 OD010445 (ORIP)
Award Recipient
:
Guido Silvestri
Funded by:
funder-id http://dx.doi.org/10.13039/100000052, NIH Office of the Director;
Award ID: P51 OD 011132
Funded by:
funder-id http://dx.doi.org/10.13039/100000052, NIH Office of the Director;
Award ID: S10 OD026799
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2116-5061
Steven E. Bosinger
Funded by:
funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: R01 AI116379
Award Recipient
:
Mirko Paiardini
Funded by:
funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: P30 AI050409
Funded by:
funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: R01 AI143411
Award Recipient
:
ORCID: https://orcid.org/0000-0002-9652-6394
Jacob D. Estes
Funded by:
National Institute of Health
Award ID: P51 OD011092
This study was funded primarily by grant R01 AI136990 from the National Institute
of Health, National Institute of Allergy and Infectious Diseases (NIAID) awarded to
S.E.B., and also supported by R24 OD010445 (ORIP) from the National Institute of Health,
Office of The Director, National Institutes of Health awarded to G.S., P51 OD 011132
from the National Institute of Health, Office of The Director awarded to the Yerkes
National Primate Center (Jonathan Lewin), S10 OD026799 from the National Institute
of Health, Office of The Director awarded to S.E.B and the Yerkes Genomics Core, grant
R01 AI116379 from the NIAID awarded to M.P., and the P30 AI050409 awarded to Carlos
Del Rio and the Center for AIDS Research (CFAR) at Emory University. The work for
this publication was supported by NIH awards R01AI143411 (J.D.E.) and P51OD011092
to Oregon National Primate Research Center (Peter Barr-Gilliespie). The funders had
no role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
SIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
SIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
SIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
SIV
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
SIV
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
SIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
SIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
SIV
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Primates
Subject:
Monkeys
Subject:
Old World monkeys
Subject:
Macaque
Subject:
Biology and life sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Primates
Subject:
Monkeys
Subject:
Old World monkeys
Subject:
Macaque
Subject:
Research and Analysis Methods
Subject:
Spectrum Analysis Techniques
Subject:
Spectrophotometry
Subject:
Cytophotometry
Subject:
Flow Cytometry
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Cloning
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Cloning
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Lymphatic System
Subject:
Lymph Nodes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Lymphatic System
Subject:
Lymph Nodes
Subject:
Medicine and health sciences
Subject:
Medical conditions
Subject:
Infectious diseases
Subject:
Viral diseases
Subject:
HIV infections
