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      Therapeutic use of the rebound effect of modern drugs: "New homeopathic medicines" Translated title: Uso terapêutico do efeito rebote dos fármacos modernos: "Novos medicamentos homeopáticos"

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          Abstract

          Summary The homeopathic treatment is based on the principle of therapeutic similitude, employing medicines that cause certain disorders to treat similar manifestations, stimulating a reaction of the organism against its own ailments. The occurrence of this secondary reaction of the organism, opposite in nature to the primary action of the medicines, is evidenced in the study of the rebound (paradoxical) effect of several classes of modern drugs. In this work, in addition to substantiate the principle of similitude before the experimental and clinical pharmacology, we suggest a proposal to employ hundreds of conventional drugs according to homeopathic method, applying the therapeutic similitude between the adverse events of medicines and the clinical manifestations of patients. Describing existing lines of research and a specific method for the therapeutic use of the rebound effect of modern drugs (http://www.newhomeopathicmedicines.com), we hope to minimize prejudices related to the homeopathy and contribute to a broadening of the healing art.

          Translated abstract

          Resumo O tratamento homeopático está fundamentado no princípio da similitude terapêutica, empregando medicamentos que causam determinados distúrbios para tratar manifestações semelhantes, estimulando uma reação do organismo contra seus próprios transtornos. A ocorrência dessa reação secundária do organismo, de natureza oposta à ação primária dos medicamentos, está evidenciada no estudo do efeito rebote (paradoxal) de inúmeras classes de fármacos modernos. Neste trabalho, além de fundamentar o princípio da similitude perante a farmacologia clínica e experimental, sugerimos uma proposta para empregar centenas de drogas convencionais segundo o método homeopático, aplicando a similitude terapêutica entre os eventos adversos dos medicamentos e as manifestações clínicas dos pacientes. Descrevendo linhas de pesquisa existentes e um método específico para o uso terapêutico do efeito rebote dos fármacos modernos (http://www.novosmedicamentoshomeopaticos.com), esperamos minimizar preconceitos relativos à homeopatia e contribuir para uma ampliação da arte de curar.

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          Most cited references52

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          Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet.

          The introduction of all-trans retinoic acid (ATRA) and, more recently, arsenic trioxide (ATO) into the therapy of acute promyelocytic leukemia (APL) has revolutionized the management and outcome of this disease. Several treatment strategies using these agents, usually in combination with chemotherapy, but also without or with minimal use of cytotoxic agents, have provided excellent therapeutic results. Cure of APL patients, however, is also dependent on peculiar aspects related to the management and supportive measures that are crucial to counteract life-threatening complications associated with the disease biology and molecularly targeted treatment. The European LeukemiaNet recently appointed an international panel of experts to develop evidence- and expert opinion-based guidelines on the diagnosis and management of APL. Together with providing current indications on genetic diagnosis, modern risk-adapted front-line therapy and salvage treatment, the review contains specific recommendations for the identification and management of most important complications such as the bleeding disorder, APL differentiation syndrome, QT prolongation and other ATRA- and ATO-related toxicities, as well as for molecular assessment of response to treatment. Finally, the approach to special situations is also discussed, including management of APL in children, elderly patients, and pregnant women.
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            beta-adrenergic receptor blockade in chronic heart failure.

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              Drug discontinuation effects are part of the pharmacology of a drug.

              Most reviews of drug withdrawal effects focus on drugs of potential abuse such as opioids, benzodiazepines, etc. Abrupt discontinuation of many other drugs used in medicine cause withdrawal syndromes, some of which can be fatal. Discontinuation of a number of cardiovascular drugs can increase risk of cardiovascular events above that of people not taking these drugs. These include β-adrenergic receptor antagonists, aspirin, HMG-CoA reductase inhibitors (statins), and heparin. Rebound hypertension occurs after abrupt cessation of many antihypertensive drugs. The possibility of discontinuation syndromes has usually been neglected until adverse clinical events force them to be noticed. Attention to the possibility of drug discontinuation effects is an important part of drug safety evaluation.
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                Author and article information

                Contributors
                Role: ND
                Journal
                ramb
                Revista da Associação Médica Brasileira
                Rev. Assoc. Med. Bras.
                Associação Médica Brasileira (São Paulo, SP, Brazil )
                0104-4230
                1806-9282
                February 2017
                : 63
                : 2
                : 100-108
                Affiliations
                [1] São Paulo São Paulo orgnameUniversidade de São Paulo orgdiv1Faculdade de Medicina orgdiv2Department of Obstetrics and Gynecology Brazil
                Article
                S0104-42302017000200100
                10.1590/1806-9282.63.02.100
                28355369
                91f36c1f-5d98-461c-a618-63f92dcd132b

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 04 July 2016
                : 09 July 2016
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 52, Pages: 9
                Product

                SciELO Brazil


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