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      Chromogranin A Messenger RNA Expression in the Rat Anterior Pituitary Is Permissively Regulated by the Adrenal Gland

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          The influence of the adrenal gland on the expression of chromogranin A in the anterior pituitary was studied in the rat. Adrenalectomy caused a progressive and pronounced (20% of control levels at day 10 after adrenalectomy) decrease of Chromogranin A mRNA levels in anterior pituitary. Daily injection of dexamethasone (15 µg/animal, s.c.) fully reversed the postadrenalectomy decrement in chromogranin A mRNA levels. Chromogranin A protein content, however, was unchanged 10 days after adrenalectomy. In contrast, pro-opiomelanocortin mRNA levels were significantly elevated after adrenalectomy and restored to normal by dexamethasone, with a time course similar to the changes in chromogranin A mRNA levels. These data demonstrate that the adrenal gland permissively regulates chromogranin A expression in the anterior pituitary, at a pretranslational locus, and that this regulation is probably mediated by glucocorticoids.

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          Author and article information

          S. Karger AG
          02 April 2008
          : 49
          : 1
          : 107-110
          aUnit on Molecular and Cellular Neurobiology, Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Md., USA, and bDepartment of Pharmacology, University of Innsbruck, Austria
          125098 Neuroendocrinology 1989;49:107–110
          © 1989 S. Karger AG, Basel

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          Pages: 4
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