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      Carvedilol in Hypertension

      Cardiology

      S. Karger AG

      Ambulatory monitoring, Beta blockers, Hypertension

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          Abstract

          Ambulatory intra-arterial blood pressure recording provides a precise and objective method for the study of antihypertensive drugs and their effects on blood pressure. Application of this technique has shown that β-adrenoreceptor-blocking drugs are only effective during the day when the subject is active. They have little effect on the early-morning rise in blood pressure, which is the time of greatest sympathetic nervous activity. Addition of a diuretic to the beta blocker produces a uniform reduction in blood pressure, which is sustained throughout the 24-hour cycle. Carvedilol is a beta blocker with alpha-blocking activity and its profile of action is similar to that of a combination of a beta blocker and a diuretic. The possession of both properties in a single molecule is advantageous.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-5874-7
          978-3-318-01680-2
          0008-6312
          1421-9751
          1993
          1993
          14 November 2008
          : 82
          : Suppl 3
          : 40-44
          Affiliations
          Division of Cardiovascular Diseases, Northwick Park Hospital and Clinical Research Centre, Harrow, Middlesex, UK
          Article
          175933 Cardiology 1993;82:40–44
          10.1159/000175933
          8106164
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Session III: Carvedilol - Clinical Experience

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