Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
23
June
2016
Publication date Collection: 2016
Volume: 11
Issue: 6
Electronic Location Identifier: e0157066
Affiliations
[1
]Novartis Vaccines & Diagnostics S.r.l., Siena, Italy
[2
]Departement of Molecular and Developmental Medicine, University of Siena, & VisMederi
S.r.l., Siena, Italy
[3
]Surrey Clinical Research Center, University of Surrey, Guildford, United Kingdom
Saint Louis University Division of Infectious Diseases and Immunology, UNITED STATES
Author notes
Competing Interests: FSp, ES, EB, LZ, RC, NC, FSc, DR, FC, DM, SB, and GDG were employee of Novartis Vaccines
& Diagnostics S.r.l. at the time of the study. FSp, ES, EB, LZ, NC, FSc, DR, DM, SB,
and GDG are now employee of GSK Vaccines S.r.l. This does not alter the authors' adherence
to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: F Spensieri FC EM. Performed the experiments:
F Spensieri EB LZ F Schiavetti RC NC DR. Analyzed the data: F Spensieri EB ES DM.
Contributed reagents/materials/analysis tools: EM. Wrote the paper: F Spensieri ES
SB DL GDG. Designed and conducted the clinical trial: DL CLB.
[¤a]
Current address: GSK Vaccines S.r.l., Siena, Italy
[¤b]
Current address: Laboratory of Immunohematology, University Hospital, Pisa, Italy
[¤c]
Current address: Center for Human Immunology, NHLBI, NIH, Bethesda, MD, United States
of America
Author information
Article
Publisher ID:
PONE-D-16-02924
DOI: 10.1371/journal.pone.0157066
PMC ID: 4918887
PubMed ID: 27336786
SO-VID: 9221a1fb-6827-4fcb-ad10-e03ab8305abe
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
Funded by: Innovative Medicines Initiative (EU)
Award ID: 115308
Award Recipient
:
David J. Lewis
These studies were funded by the Innovative Medicines Initiative Joint Undertaking
under grant agreement no. 115308, resources of which are composed of financial contribution
from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’
in kind contribution. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Vaccines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Vaccines
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Vaccines
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Viral Diseases
Subject:
Influenza
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Antibody Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Antibody Response
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1