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      Physiological Roles of Integrin α 6β 1 in Ovarian Functions

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          Abstract

          We previously reported that human ovarian cells express integrin β<sub>1</sub> families. The physiological role(s) of integrins was investigated using in vitro human granulosa cell culture and in vivo mouse ovulation model. In human luteinizing granulosa cell culture obtained from the patients undergoing in vitro fertilization treatment, laminin, which is a ligand for integrin α<sub>6</sub>β<sub>1</sub>, suppressed the production of progesterone by granulosa cells. On the other hand, the anti-α<sub>6</sub> monoclonal antibody (mAb) GoH3, which partially inhibits the interaction between integrin α<sub>6</sub>β<sub>1</sub> and laminin, enhanced production of progesterone by 2-fold of the control under the culture with laminin, indicating that integrin α<sub>6</sub>β<sub>1</sub> regulates the luteinization of human granulosa cell during the periovulatory phase. In an immature superovulated 13-day-old ICR (CD-1) mice model, intraperitoneal administration of GoH3 induced successful ovulation, whereas no ovulation was observed in the GoH3-nontreated groups, showing that integrin α<sub>6</sub>β<sub>1</sub> is related to gonadotropin-induced follicular growth. These findings suggest that the interaction between integrin α<sub>6</sub>β<sub>1</sub> and laminin plays an important role in the corpus luteum formation and follicular growth.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6735-0
          978-3-318-00336-9
          1663-2818
          1663-2826
          1998
          July 1998
          17 November 2004
          : 50
          : Suppl 2
          : 25-29
          Affiliations
          a Department of Gynecology and Obstetrics, Faculty of Medicine, b Virus Research Institute, c Chest Disease Research Institute, Kyoto University, d Kyoto National Hospital, Kyoto, and e Department of Obstetrics and Gynecology, Kobe City General Hospital, Kobe, Japan
          Article
          53120 Horm Res 1998;50(suppl 2):25–29
          10.1159/000053120
          9721588
          9223987c-66a6-4cda-802b-b7419b61e2f3
          © 1998 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 5
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Extracellular matrix,Integrin,Follicular growth,Ovary,Corpus luteum formation

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