3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      CD44 and its partners in metastasis.

      1
      Clinical & experimental metastasis
      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The establishment of metastasis requires that tumor cells acquire new adhesion and migration properties to emigrate from primary sites and colonize distant organs. CD44 is a cell membrane protein often overexpressed on tumor cells and, being both a cell-cell and cell-extracellular matrix adhesion protein, is well positioned to contribute to this process. Furthermore the interaction of CD44 with other cellular proteins involved in motogenesis and proteolysis is a determinant factor in cell migration and invasion. This review summarizes current knowledge on the role of CD44 in metastasis, as well as the challenges on understanding how this process operates.

          Related collections

          Author and article information

          Journal
          Clin Exp Metastasis
          Clinical & experimental metastasis
          Springer Science and Business Media LLC
          0262-0898
          0262-0898
          2003
          : 20
          : 3
          Affiliations
          [1 ] Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada. jothys@smh.toronto.on.ca
          Article
          10.1023/a:1022931016285
          12741678
          9254e009-5de5-4eb9-86ff-3052b3fb4f80
          History

          Comments

          Comment on this article