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Altered cerebral activity associated with topiramate and its withdrawal in patients with epilepsy with language impairment: An fMRI study using the verb generation task.

Author(s): Dong Zhou, Qiyong Gong, Qin Chen, Luo Ouyang, Xiaoqi Huang, Chunyan Luo, Su Lui, Xintong Wu, Bo Zhou, Xiaofeng Yu, Wei B Xia, Yingying Tang

Publication date: 2016-06-01

Journal: Epilepsy & behavior : E&B

Publisher: Elsevier BV

Keywords: Language, Functional magnetic resonance imaging (fMRI), Epilepsy, Topiramate (TPM)

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Abstract

Topiramate (TPM) is well recognized for its negative effects on language in healthy volunteers and patients with epilepsy. The aim of this study was to investigate the brain activation and deactivation patterns in TPM-treated patients with epilepsy with language impairment and their dynamic alteration during TPM withdrawal using functional magnetic resonance imaging (fMRI) with the verb generation task (VGT).

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PubMed ID:: 27123530

DOI:: 10.1016/j.yebeh.2016.03.013

Keywords: Language,Functional magnetic resonance imaging (fMRI),Epilepsy,Topiramate (TPM)

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Keywords: Language, Functional magnetic resonance imaging (fMRI), Epilepsy, Topiramate (TPM)

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