83
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener.

      The EMBO Journal

      Animals, Arteries, drug effects, metabolism, Blood Pressure, Cardiovascular System, Cell Separation, Cells, Cultured, Cystathionine gamma-Lyase, genetics, Cysteine, Endothelium, Vascular, Hydrogen Sulfide, administration & dosage, In Situ Hybridization, In Vitro Techniques, Injections, Intravenous, Male, Membrane Potentials, Muscle, Smooth, Vascular, cytology, Nitric Oxide, pharmacology, Potassium Channel Blockers, Potassium Channels, RNA, Messenger, Rats, Rats, Sprague-Dawley, Vasodilation, physiology, Vasodilator Agents, Vasomotor System

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Hydrogen sulfide (H(2)S) has been traditionally viewed as a toxic gas. It is also, however, endogenously generated from cysteine metabolism. We attempted to assess the physiological role of H(2)S in the regulation of vascular contractility, the modulation of H(2)S production in vascular tissues, and the underlying mechanisms. Intravenous bolus injection of H(2)S transiently decreased blood pressure of rats by 12- 30 mmHg, which was antagonized by prior blockade of K(ATP) channels. H(2)S relaxed rat aortic tissues in vitro in a K(ATP) channel-dependent manner. In isolated vascular smooth muscle cells (SMCs), H(2)S directly increased K(ATP) channel currents and hyperpolarized membrane. The expression of H(2)S-generating enzyme was identified in vascular SMCs, but not in endothelium. The endogenous production of H(2)S from different vascular tissues was also directly measured with the abundant level in the order of tail artery, aorta and mesenteric artery. Most importantly, H(2)S production from vascular tissues was enhanced by nitric oxide. Our results demonstrate that H(2)S is an important endogenous vasoactive factor and the first identified gaseous opener of K(ATP) channels in vascular SMCs.

          Related collections

          Author and article information

          Journal
          11689441
          125693
          10.1093/emboj/20.21.6008

          Comments

          Comment on this article