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      A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity

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          Abstract

          Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature.

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          Most cited references153

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          Medicinal Plants in Tropical West Africa

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            Indian Medicinal Plant – An Illustrated Dictionary

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              Effect of methanolic extract of Balanites aegyptiaca fruits on enteral and parenteral stages of Trichinella spiralis in rats.

              There is a considerable interest in developing new anthelmintic drugs including those from medicinal plants due to increasing evidence of parasitic resistance against present anthelmintic drugs and decreasing activity against encapsulated larval stages of parasites. This study was carried out to assess, for the first time, the effectiveness of methanolic extract of Balanites aegyptiaca (BAE) fruits against different stages (pre-adult, migrating larvae, and encysted larvae) of Trichinella spiralis in rats compared with commonly used anthelmintic albendazole. Oral administration of BAE at a dose of 1,000 mg/kg b.wt. for five successive days throughout the parasite life cycle led to a marked reduction of migrating and encysted larval rate by 81.7% and 61.7%, respectively, in the muscular tissue. This treatment was less effective against adults in the gut (47.8%). Albendazole treatment at a dose of 10 mg/kg b.wt. for five successive days resulted in a marked eradication of T. spiralis adult worms (94.4%) and less reduction of migrating and encysted larval infections of skeletal muscles (62.2% and 26.4%, respectively). BAE-treated groups showed marked decreases in serum-glucose levels, triglyceride concentrations, aspartate aminotransferase (AST), creatinine phosphokinase (CPK) activities, and lipid peroxide products (malondialdehyde, MDA) as well as an increase in glutathione level in both serum and muscular tissue compared to albendazole-treated- and infected-untreated groups. This result was confirmed by few numbers of living- and dead-encysted larvae and less destruction of the diaphragm and skeletal muscle tissues in BAE-treated groups compared to other treated groups. It can be concluded that the methanolic extract of B. aegyptiaca fruits has high effectiveness against parenteral stages of T. spiralis than albendazole. Albendazole is more effective against enteral stage of T. spiralis than the extract.
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                Author and article information

                Journal
                Pharmacogn Rev
                PRev
                Pharmacognosy Reviews
                Medknow Publications Pvt Ltd (India )
                0973-7847
                0976-2787
                Jan-Jun 2011
                : 5
                : 9
                : 55-62
                Affiliations
                [1] Department of Pharmacognosy, Pioneer Degree Pharmacy College, Vadodara, Gujarat, India
                [1 ] Department of Pharmacognosy, Sun Pharma Advanced Research Company (SPARC Ltd.) Baroda, Gujarat, India
                Author notes
                Address for correspondence: Ms. Daya L. Chothani Pioneer degree pharmacy college, Baroda-Vadodara, India E-mail: dayachothani@ 123456yahoo.co.in
                Article
                PRev-5-55
                10.4103/0973-7847.79100
                3210005
                22096319
                928d1c70-c158-4e03-a339-3294a8f3f2ea
                © Pharmacognosy Reviews

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 20 August 2010
                Categories
                Review Article

                Pharmacology & Pharmaceutical medicine
                balanites aegyptiaca,balanitin,desert date
                Pharmacology & Pharmaceutical medicine
                balanites aegyptiaca, balanitin, desert date

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