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      Developmental basis of vascular smooth muscle diversity.

      Arteriosclerosis, Thrombosis, and Vascular Biology

      cytology, Stem Cells, Somites, Signal Transduction, metabolism, Serum Response Factor, Phenotype, Pericardium, Neural Crest, Myocytes, Smooth Muscle, Myoblasts, Smooth Muscle, embryology, Muscle, Smooth, Vascular, genetics, Muscle Development, Microcirculation, Humans, Gene Expression Regulation, Developmental, Epithelium, Cell Proliferation, Cell Lineage, Cell Differentiation, pathology, Cardiovascular Diseases, Animals

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          Abstract

          The origins of vascular smooth muscle are far more diverse than previously thought. Lineage mapping studies show that the segmental organization of early vertebrate embryos leaves footprints on the adult vascular system in the form of a mosaic pattern of different smooth muscle types. Moreover, evolutionarily conserved tissue forming pathways produce vascular smooth muscle from a variety of unanticipated sources. A closer look at the diversity of smooth muscle origins in vascular development provides new perspectives about how blood vessels differ from one another and why they respond in disparate ways to common risk factors associated with vascular disease. The origins of vascular smooth muscle are far more diverse than previously thought. A closer look at the diversity of smooth muscle origins in vascular development provides new perspectives about how blood vessels differ from one another and why they respond in disparate ways to common risk factors associated with vascular disease.

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          Journal
          10.1161/ATVBAHA.107.141069
          17379839

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