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      Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation

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      The Lancet

      Elsevier BV

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          Most cited references 17

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          Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness.

          Living skin-equivalent grafts consisting of fibroblasts cast in collagen lattices and seeded with epidermal cells were successfully grafted onto the donors of the cells. The grafts were vascularized, did not evoke a homograft reaction, inhibited wound contraction, filled the wound space, and persisted.
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            Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation.

            A new approach for tissue creation using synthetic biocompatible and biodegradable polymers as templates onto which cells are seeded is presented. This report concerns the generation of homogeneous plates of stable mature cartilage in vivo. The delivery of chondrocytes on synthetic polymers configured to provide a large surface area for cell attachment and thus to allow cell function and survival by diffusion of nutrients has resulted in the creation of macroscopic plates of up to 100 mg of new cartilage subcutaneously in 19 of 21 animals. The approximate dimensions and configuration of the original templates were maintained as new cartilage was formed and the polymers resorbed.
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              Selective cell transplantation using bioabsorbable artificial polymers as matrices

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                Author and article information

                Journal
                The Lancet
                The Lancet
                Elsevier BV
                01406736
                July 1999
                July 1999
                : 354
                :
                : S32-S34
                Article
                10.1016/S0140-6736(99)90247-7
                10437854
                © 1999

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