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Abstract
The aim of this study was to identify the most appropriate timing for surgery in newborns
with choledochal cysts.
The clinical and histological data of 8 newborn cases of choledochal cysts (newborn
group) were compared with 45 cases that were diagnosed later than the newborn period
(late group).
The mean and standard deviation of age at diagnosis was 0.4+/-0.4 months and 43.4+/-37.8
months in the newborn and late group, respectively. The age at operation was significantly
earlier in the newborn group than in the late group (4.9+/-4.5 months v54.7+/-47.0
months). Although no significant difference in the time that elapsed between the operation
and the onset of symptoms between the newborn and late groups (4.5+/-4.7 months v11.3+/-21.1
months), the serum bilirubin level (4.6+/-3.8 mg/dL v1.8+/-3.4 mg/dL) and the grade
of liver fibrosis (2.0+/-0.8 v1.1+/-0.8) were significantly higher in the newborn
group than in the late group.
The newborn group should be considered as a special group of patients with different
clinical course and pathology than those of the late group, which necessitate the
early surgical intervention to prevent progression of liver fibrosis.