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      Review of the Ischemia Hypothesis for Ocular Hypertension Other than Congenital Glaucoma and Closed-Angle Glaucoma

      Ophthalmologica

      S. Karger AG

      Ocular hypertension, Open-angle glaucoma, Etiology, Ischemia, Monkey eye, Pigeon eye

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          Abstract

          Experimentally induced ischemia of the endothelial cells surrounding the aqueous drainage sites led to a rise in intraocular pressure (IOP) in monkey and pigeon eyes. Clinical conditions associated with a rise in IOP in human eyes, e.g. peripheral retinal detachments, subluxated lenses, and occlusion of the internal carotid artery, can result in ischemia of the endothelial cells lining Schlemm’s canal. These findings led to the hypothesis that ischemia of the endothelial cells of Schlemm’s canal induces hypertension in human eyes. Thus, the ischemia hypothesis should be considered in discussions of the etiology of age-related open-angle glaucoma.

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          Most cited references 4

          • Record: found
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          Identification of a Gene That Causes Primary Open Angle Glaucoma

           E Stone (1997)
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            • Record: found
            • Abstract: not found
            • Article: not found

            Ischemic Hypertension of Pigeon Eye

             M Nakabayashi (2001)
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              • Record: found
              • Abstract: not found
              • Article: not found

              The occurrence of senile cataracts, ocular hypertension and glaucoma in rhesus monkeys

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                Author and article information

                Journal
                OPH
                Ophthalmologica
                10.1159/issn.0030-3755
                Ophthalmologica
                S. Karger AG
                0030-3755
                1423-0267
                2004
                October 2004
                26 July 2010
                : 218
                : 5
                : 344-349
                Affiliations
                Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
                Article
                79477 Ophthalmologica 2004;218:344–349
                10.1159/000079477
                15334016
                © 2004 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 1, References: 37, Pages: 6
                Categories
                Original Paper

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