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      Traction Therapy for Cervical Radicular Syndrome is Statistically Significant but not Clinically Relevant for Pain Relief. A Systematic Literature Review with Meta-Analysis and Trial Sequential Analysis

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          Abstract

          Aim: We aimed to investigate the effectiveness of traction therapy in reducing pain by performing a systematic review with meta-analysis. We also explore the best modality for administering traction to patients with cervical radicular syndrome (CRS). Methods: We searched the Medline, Physiotherapy Evidence Database (PEDro), Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) electronic databases. Two reviewers independently selected randomized controlled trials (RCTs) that compared traction in addition to other treatments versus the effectiveness of other treatments alone for pain outcome. We calculated the mean differences (MDs) and 95% confidence intervals (CIs). We used Cochrane’s tool to assess risk of bias and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to evaluate the quality of evidence and summarize the study conclusions. Results: A total of seven studies (589 patients), one with low risk of bias, were evaluated. An overall estimate of treatment modalities showed low evidence that adding traction to other treatments is statistically significant (MD −5.93 [95% CI, −11.81 to −0.04] P = 0.05 and I 2 = 57%) compared to other treatments alone. The subgroup analyses were still statistically significant only for mechanical and continuous modalities. Conclusions: Overall analysis showed that, compared to controls, reduction in pain intensity after traction therapy was achieved in patients with cervical radiculopathy. However, the quality of evidence was generally low and none of these effects were clinically meaningful.

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          Most cited references55

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          Measuring inconsistency in meta-analyses.

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            The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials

            Flaws in the design, conduct, analysis, and reporting of randomised trials can cause the effect of an intervention to be underestimated or overestimated. The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate
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              Meta-analysis in clinical trials

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                Author and article information

                Journal
                J Clin Med
                J Clin Med
                jcm
                Journal of Clinical Medicine
                MDPI
                2077-0383
                22 October 2020
                November 2020
                : 9
                : 11
                : 3389
                Affiliations
                [1 ]Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal-Infantile Sciences, University of Genoa, 16121 Genoa, Italy; colombo.claudio92@ 123456gmail.com (C.C.); stefano.salvioli@ 123456gmail.com (S.S.); marco.testa@ 123456unige.it (M.T.)
                [2 ]Unit of Clinical Epidemiology, IRCCS Istituto Ortopedico Galeazzi, 20162 Milan, Italy; greta.castellini@ 123456grupposandonato.it
                Author notes
                [* ]Correspondence: silvia.gianola@ 123456grupposandonato.it ; Tel.: + 02-66214057
                Author information
                https://orcid.org/0000-0002-7828-9241
                https://orcid.org/0000-0002-1489-5322
                https://orcid.org/0000-0003-3770-0011
                https://orcid.org/0000-0002-3345-8187
                https://orcid.org/0000-0001-8643-7200
                Article
                jcm-09-03389
                10.3390/jcm9113389
                7690405
                33105668
                92eb25f1-b8a8-4376-87d9-2dcaa57fced1
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 26 September 2020
                : 19 October 2020
                Categories
                Review

                cervical radiculopathies,traction,meta-analysis,systematic review,trial sequential analysis,evidence-based practice

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