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      Butyrate as a differentiating agent: pharmacokinetics, analogues and current status.

      Cancer Letters
      Anemia, Sickle Cell, drug therapy, Antineoplastic Agents, Butyrates, pharmacokinetics, pharmacology, Cell Differentiation, drug effects, Humans, Leukemia, Thalassemia

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          Abstract

          The field of butyrate-induced differentiation of neoplastic and non-neoplastic cells is reviewed and possible clinical correlations considered with regard to butyrate, butyrate prodrugs and butyrate analogues. These topics are discussed from the point of view of the concentrations required in vitro for biologic effect, and likely pharmacokinetic behavior in vivo.

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          Author and article information

          Journal
          8180951
          10.1016/0304-3835(94)90023-X

          Chemistry
          Anemia, Sickle Cell,drug therapy,Antineoplastic Agents,Butyrates,pharmacokinetics,pharmacology,Cell Differentiation,drug effects,Humans,Leukemia,Thalassemia

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