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      Cardiac dysfunction in beta-thalassemic children.

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          Abstract

          The biventricular systolic function was evaluated by M mode and Doppler echocardiography in 16 patients with homozygous beta-thalassemia and beta-thalassemia Hb E disease, aged 5-14 yrs (9.9 +/- 2.4 yr). The left ventricular end-diastolic dimension and left ventricular mass were increased in 88 per cent of the patients. Left ventricular fractional shortening and cardiac index were normal in all but one patient. Fifteen patients had evidence of pulmonary artery hypertension manifested by abnormality in the ratio of right ventricular acceleration time to ejection time (AT/ET). There was good correlation between platelets count and AT/ET (r = -0.70, P = 0.002). Thrombocytosis was noted in 4 patients. Our findings indicated that in beta-thalassemic children, right ventricular dysfunction was detected earlier than left ventricular dysfunction and platelets may play a role in the pathogenesis of pulmonary artery hypertension.

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          Author and article information

          Journal
          J Med Assoc Thai
          Journal of the Medical Association of Thailand = Chotmaihet thangphaet
          0125-2208
          0125-2208
          Nov 1993
          : 76
          : 11
          Affiliations
          [1 ] Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
          Article
          7964232

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