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      Nitrite inhibition of Clostridium botulinum: electron spin resonance detection of iron-nitric oxide complexes.

      Science (New York, N.Y.)
      Clostridium botulinum, drug effects, Electron Spin Resonance Spectroscopy, Iron, Iron-Sulfur Proteins, antagonists & inhibitors, Metalloproteins, Nitric Oxide, Nitrites, pharmacology

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          Abstract

          Vegetative cells of Clostridium botulinum were shown to contain iron-sulfur proteins that react with added nitrite to form iron-nitric oxide complexes, with resultant destruction of the iron-sulfur cluster. Inactivation of iron-sulfur enzymes (especially ferredoxin) by binding of nitric oxide would almost certainly inhibit growth, and thus is probably the mechanism of botulinal inhibition by nitrite in foods.

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