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      Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.

      Nature

      Transfection, Amino Acid Oxidoreductases, Tissue Distribution, Sequence Homology, Nucleic Acid, Rats, genetics, analysis, RNA, Messenger, Phosphorylation, Nitric Oxide Synthase, NADPH-Ferrihemoprotein Reductase, metabolism, NADP, Molecular Sequence Data, Humans, Gene Expression, Flavin-Adenine Dinucleotide, Flavin Mononucleotide, DNA, Cloning, Molecular, enzymology, Cerebellum, Cell Line, Calmodulin, Binding Sites, Base Sequence, Animals, Amino Acid Sequence, chemistry

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          Abstract

          Nitric oxide is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors. The only known mammalian enzyme with close homology is cytochrome P-450 reductase.

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          Journal
          10.1038/351714a0
          1712077

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