Disgust is a multifaceted experience that might affect several aspects of life. Here, we reviewed research on neurological and psychiatric disorders that are characterized by abnormal disgust processing to test the hypothesis of a shared neurocognitive architecture in the representation of three disgust domains: i) personal experience of 'core disgust'; ii) social disgust, i.e., motor and vocal expressions of disgust; iii) moral disgust, i.e., sensitivity to ethical violations. Our analysis provides some support to the shared neurocognitive hypothesis and suggests that the insula might be the "hub" structure linking the three domains of disgust sensitivity, while other brain regions may subserve specific facets of the multidimensional experience. Our review also suggests a role of monoamines in disgust processing. In particular, 5-HT appears to be implicated in core and moral disgust processing, while DA might be mainly involved in the processing of social disgust. Finally, our results are consistent with "neo-sentimentalist" theories of morality, which posits a causal role of affect in moral judgment.