Decreased serum magnesium in obese Thai children with metabolic syndrome

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Abstract

Abstract. Setting: A prospective cohort study with convenience sampling was conducted on 26 overweight children and 26 lean controls aged between 7 and 14 years. Demographic and clinical characteristics were collected and an oral glucose tolerance test was performed with 1.75 g/kg body weight glucose. Blood samples were taken at 0 and 2 hours. Results: The overweight children exhibited all criteria of metabolic syndrome: body mass index of 33 kg/m 2 , hyperglycemia, hyperinsulinemia, HOMA-IR-score of 5.04, increased blood pressure and triglycerides. Serum magnesium (Mg) was decreased and negatively correlated to serum-insulin, HOMA-IR-score, degree of obesity, triglycerides, and positively correlated to HDL cholesterol. Obese children presented with muscle cramps (8%) and cardiac events (12%). Mg depletion is probably due to glucosuria and hyperinsulinemia. Recommendation: Restriction of caloric intake, increased physical activity, plentiful Mg intake. 

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Copper and carcinogenesis.

T Theophanides, J Anastassopoulou (2002)

Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O2-* and *OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases.

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Serum ceruloplasmin and copper levels in patients with primary brain tumors.

L Turecký, P Kalina, E Uhlíková … (1984)

Serum copper and ceruloplasmin levels are known to increase in several malignancies such as osteosarcomas, some gastrointestinal tumors, and lung cancer. In this study serum copper and ceruloplasmin levels in 40 patients with primary brain tumors were studied. Both parameters were increased in sera of patients with tumors in comparison with healthy subjects or patients with non-tumorous neurological diseases. It is concluded that copper and ceruloplasmin represent a good complement to some other nonspecific parameters in evaluating the activity of malignancy and the therapeutic results.

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Interleukin 7 is produced by murine and human keratinocytes

G Schuler, F von Koch, C Heufler … (1993)

Interleukin 7 (IL-7) was originally identified as a growth factor for B cell progenitors, and subsequently has been shown to exert proliferative effects on T cell progenitors and mature peripheral T cells as well. Constitutive IL-7 mRNA expression so far had been demonstrated in bone marrow stromal cell lines, thymus, spleen, and among nonlymphoid tissues in liver and kidney. Here we show that both murine and human keratinocytes express IL-7 mRNA and release IL-7 protein in biologically relevant amounts. The physiological or pathological relevance of keratinocyte-derived IL-7 is presently unknown. Our finding that keratinocytes can produce IL-7 in concert with reports that IL-7 is a growth factor for in vivo primed antigen- specific T cells, as well as for T lymphoma cells suggests, however, that keratinocyte-derived IL-7 is important in the pathogenesis of inflammatory skin diseases and cutaneous T cell lymphoma.