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      Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review

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          Abstract

          Purpose

          Currently, there is an increasing interest regarding the impact of COVID-19 on the thyroid function. As several recent reports have described the onset of thyroid dysfunction in patients diagnosed with COVID-19, we performed a systematic review to assess the prevalence of thyroid dysfunction in patients with COVID-19 as this information could be clinically relevant for the management of these patients.

          Methods

          A comprehensive computer literature search using PubMed/Medline and Cochrane databases was performed until November 14, 2020 to search original articles evaluating thyroid dysfunction in COVID-19 patients. Information about thyroid dysfunction assessed by thyroid function test was retrieved by the eligible articles. Qualitative analysis (systematic review) only was performed whether a significant heterogeneity of data was detected.

          Results

          Seven studies including 1237 patients with COVID-19 were included. A significant heterogeneity across the studies was found. Most COVID-19 patients were euthyroid with TSH levels in the normal range (from 44 to 94% of the COVID-19 patients assessed in the included studies). The prevalence of thyroid dysfunction in COVID-19 patients (defined as abnormal thyroid function tests) largely varies among the included studies between 13 and 64% of COVID-19 patients as well as clinical presentation. A positive correlation between thyroid dysfunction and clinical severity of COVID-19 was reported.

          Conclusion

          Literature data show that thyroid dysfunction is present in a significant percentage of patients with COVID-19. Assessment of thyroid function may be considered in symptomatic COVID-19 patients to have a baseline before introducing thyroid-interfering drugs and those requiring high-intensity care. Further, well-designed studies are needed to better elucidate the impact of COVID-19 on thyroid function and inform thyroid function testing and thyroid dysfunction management in COVID-19 patients.

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          Most cited references17

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          Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

          David Moher and colleagues introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses
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            Thyrotoxicosis in patients with COVID-19: the THYRCOV study

            Objective This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection. Design and methods This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, median age: 66 years, range: 27–92) hospitalized for COVID-19 in non-intensive care units. Results Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), and 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho −0.27; P < 0.001) and IL-6 (rho −0.41; P < 0.001). In the multivariate analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio: 3.25, 95% confidence interval: 1.97–5.36; P < 0.001), whereas the association with age of patients was lost ( P = 0.09). Conclusions This study provides first evidence that COVID-19 may be associated with high risk of thyrotoxicosis in relationship with systemic immune activation induced by the SARS-CoV-2 infection.
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              SARS-CoV-2-related atypical thyroiditis

              The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1, 2 has seriously affected northern Italy. Preliminary data analysis of patients with COVID-19 who required high intensity of care at our institution (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy) showed that these individuals commonly had low or suppressed serum thyroid stimulating hormone, with and without elevated free thyroxine concentrations, which suggests thyrotoxicosis. Patients who are critically ill can have alterations of thyroid function tests, known as non-thyroidal illness syndrome.3, 4 Alternatively, thyrotoxicosis could result from SARS-CoV-2 directly infecting the thyroid gland, as described in other viral infections. Infection of the thyroid gland is known as subacute thyroiditis and is characterised by self-limiting thyrotoxicosis of variable duration—lasting a period of weeks or months—followed by hypothyroidism with final restoration of euthyroidism.5, 6 We aimed to assess the prevalence of thyrotoxicosis, suggestive for subacute thyroiditis, in patients admitted to high intensity of care units (HICUs) in relation to the presence or absence of COVID-19. To this end, we compared patients admitted to HICUs in 2020 because of COVID-19 (HICU-20 group), with those admitted to the same HICUs in 2019, thus SARS-CoV-2 negative (HICU-19 group). Estimating a prevalence of subacute thyroiditis of 0·5% in the HICU-19 group, in line with the general population, 5 and of 10% in the HICU-20 group, a total of 166 patients were needed to obtain a 80% statistical power and a significance of 0·05 (two tails). Thyroid function was assessed at hospital admittance (within an average of 2 days) in 93 consecutive patients in the HICU-20 group and 101 consecutive patients in the HICU-19 group. 52 patients with COVID-19 who were admitted to low intensity of care units (LICU-20 group) were also studied (appendix p 4). Patients in the HICU-20 group were younger than those in the other two groups (65·3 [SD 12·9] years in the HICU-20 group, 73·0 [15·2] years in the HICU-19 group, and 70·3 [18·1] years in the LICU-20 group; p=0·0019). The HICU-20 group had more men than the other two groups (64 [69%] of 93 in the HICU-20 group, 57 [56%] of 101 in the HICU-19 group, and 25 [48%] of 52 in the LICU-20 group; p=0·038). Thyroid diseases are more common in women, which was reflected in the number of patients with pre-existing thyroid disorders: 23 (23%) of 101 in the HICU-19 group, 11 (21%) of 52 in the LICU-20 group, and 8 (9%) of 93 in the HICU-20 group (p=0·017). These patients were excluded from the thyroid function analysis (appendix p 4). As many as 13 (15%) of 85 patients in the HICU-20 group were thyrotoxic, compared with one (1%) of 78 patients in the HICU-19 group (p=0·002) and one (2%) of 41 patients in the LICU-20 group (p=0·025). Of the 14 patients with COVID-19 and thyrotoxicosis, more were men (nine [64%] men and five [36%] women; p=0·017). Patients in the HICU-20 group had lower serum thyroid stimulating hormone concentrations than did patients in the HICU-19 and LICU-20 groups (p=0·018; figure 1A ). Mean serum free thyroxine concentrations were higher in the HICU-20 group than in the LICU-20 group (p=0·016), but not the HICU-19 group (p=0·38; appendix p 4). Stratification for sex and age did not affect the results (data not shown). Figure 1 Distribution of serum thyroid stimulating hormone (A) and box plots of C-reactive protein (B) concentrations in patients admitted to high or low intensity of care units Date are expressed as median (IQR). (A) Patients with known thyroid disorders at hospitalisation were not included. Serum thyroid stimulating hormone was 1·43 (0·88–2·37) mIU/L in the HICU-19 group; 1·04 (0·47–1·80) mIU/L in the HICU-20 group; and 1·43 (0·71–2·28) in the LICU-20 group (p=0·018). The HICU-20 group had a lower thyroid stimulating hormone concentration than the HICU-19 group (p=0·009) and the LICU-20 group (p=0·045). (B) C-reactive protein concentrations were 66 (15–121) mg/L in the HICU-19 group; 96 (51–177) mg/L in the HICU-20 group; and 52 22–103 mg/L in the LICU-20 group (p=0·0038). HICU=high intensity of care unit. LICU=low intensity of care unit. *78 patients admitted to HICUs in 2019. †85 patients admitted to HICUs in 2020. ‡41 patients admitted to LICUs in 2020. Although the dramatic increase in the number of patients requiring hospitalisation because of the COVID-19 pandemic emergency might have meant that patients in the HICU-20 group were admitted in more critical conditions compared with those in the HICU-19 group, the thyroid dysfunction observed in the HICU-20 group is unlikely to be related to non-thyroidal illness syndrome only. There was no significant difference between the free tri-iodothyronine concentrations, the main non-thyroidal illness syndrome indicator, which were low in all groups (p=0·71; appendix p 4). In patients with non-thyroidal illness syndrome, normal or low serum concentrations of thyroid stimulating hormone and low concentrations of tri-iodothyronine are usually associated with low concentrations of thyroxine;3, 4 however, in our cohort of patients with COVID-19, low concentrations of thyroid stimulating hormone and tri-iodothyronine were associated with normal or elevated concentrations of thyroxine. A transient thyroxine increase over a period of hours can occur in acute conditions, usually associated with normal or high serum thyroid stimulating hormone concentrations, 3 but not low concentrations as observed in this study. It is plausible that our patients might have had a combination of thyrotoxicosis and non-thyroidal illness syndrome, described as thyroxine thyrotoxicosis. 4 To test this hypothesis, eight patients with COVID-19 and any thyroid dysfunction observed at hospital admission were followed-up after a mean of 55 (SD 8) days following discharge when negative for SARS-CoV-2 (appendix p 6). Two (25%) patients were confirmed to have hypothyroidism and had marked diffuse hypoechogenicity and heterogeneity at thyroid ultrasound, characteristic features of autoimmune thyroiditis. The six (75%) patients with low or suppressed thyroid stimulating hormone concentrations or thyrotoxicosis at baseline had normal thyroid function and were negative for thyroid autoantibodies at follow-up; none reported neck pain ever. The six patients had a diffuse mild hypoechoic pattern at thyroid ultrasound. Three patients had focal markedly hypoechoic areas. Such areas corresponded to focal reduced Technetium-99m uptake at single-photon emission CT imaging, and the thyroid gland showed a general low to normal or reduced Technetium-99m uptake, which suggested subacute thyroiditis (appendix p 7). It is plausible that we might have missed some typical imaging features of subacute thyroiditis in the other three patients because of the time elapsed between hospital admission and follow-up and the anti-inflammatory treatments received. Our work suggests that a substantial proportion of patients with COVID-19, requiring high intensity of care, present with thyrotoxicosis and low serum thyroid stimulating hormone concentrations, possibly as a consequence of subacute thyroiditis induced by SARS-CoV-2, in an underlying setting of non-thyroidal illness syndrome. Patients in the HICU-20 group also had a lower prevalence of both autoimmune and non-autoimmune pre-existing thyroid disorders compared with the HICU-19 group; this suggests that such conditions are not a risk factor for SARS-CoV-2 infection or severity of COVID-19. In patients with COVID-19 requiring high intensity of care and presenting with subacute thyroiditis, serum free thyroxine concentrations were not as elevated and serum thyroid stimulating hormone concentrations not as suppressed, as described in the classic subacute thyroiditis. 6 These patients also did not complain of neck pain (consistent with silent thyroiditis), did not have leucocytosis, but did have lymphopenia, as observed with COVID-19 infection (appendix p 6). 2 These features differ from those described in the first case report of late-onset thyroiditis after mild SARS-CoV-2 infection, 7 and reports of classic subacute thyroiditis, characterised by a pathognomonic infiltration of giant cells (congregates of lymphocytes, histiocytes, and colloid), with swelling of thyroid follicles, stretching of the thyroid capsule, and consequent neck pain. 6 In SARS-CoV-2 related thyroiditis, giant cells might not form because of lymphopenia and thyroid cells might be damaged by apoptosis, as observed with severe acute respiratory syndrome coronavirus (SARS-CoV). 8 The angiotensin-converting enzyme 2 (ACE2) is a host-cell entry receptor for both SARS-CoV and SARS-CoV-2, 1 and it might be partly responsible for a common pathogenic pathway. ACE2 is more highly expressed in thyroid cells than in lung cells, and in women such expression negatively correlates with signatures of immune cell enrichment. 9 This expression profile might explain why in this study the most severe forms of COVID-19 pneumonia 2 and associated thyroid dysfunction were predominantly reported in men in the HICU-20 group, but not women as in the classic viral subacute thyroiditis. 6 Serum C-reactive protein concentration is a general non-specific marker of inflammation, subacute thyroiditis, 10 and COVID-19 disease severity. 2 Median serum C-reactive protein concentrations were significantly higher in the HICU-20 group compared with the HICU-19 ad LICU-20 groups (p=0·0038; figure 1B; appendix p 4). In patients with COVID-19, median serum C-reactive protein, but not median thyroid stimulating hormone and mean free thyroxine concentrations, were significantly higher in patients that died than in survivors (median 190 mg/L [IQR 94–256] in patients that died vs 73 mg/L [33–133] mg/L in patients that survived; p=0·0052; not shown). This difference was not observed in the HICU-19 group (p=0·27). It could be speculated that patients with higher serum C-reactive protein concentrations might have a systemic spread of SARS-CoV-2 that is more likely to affect the thyroid gland. This is the first comprehensive description of thyroid alterations in hospitalised patients with COVID-19 with initial longitudinal follow-up available; however, this work has limitations. Serum free thyroxine and free tri-iodothyronine concentrations were measured when thyroid stimulating hormone concentrations were less than 0·45 mIU/L and thyroxine concentrations were measured when thyroid stimulating hormone concentrations were more than 3·50 mIU/L (appendix p 2), thyroid imaging was done nearly two months after baseline thyroid stimulating hormone measurement because of prolonged post-discharge persistence of SARS-CoV-2 positivity, and serum thyroid stimulating hormone analysis was not available in all patients in the LICU-20 group. In conclusion, we suggest routine assessment of thyroid function in patients with COVID-19 requiring high intensity care, because they frequently present with thyrotoxicosis due to a form of subacute thyroiditis related to SARS-CoV-2. Considering the currently ongoing pandemic emergency, future studies are encouraged to confirm, or counter, these results. Thyroid cytology or histology and longitudinal studies of thyroid (dys)function in these patients would be particularly informative.
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                Author and article information

                Contributors
                luca.giovanella@eoc.ch
                Journal
                Clin Transl Imaging
                Clin Transl Imaging
                Clinical and Translational Imaging
                Springer International Publishing (Cham )
                2281-5872
                2281-7565
                11 March 2021
                : 1-8
                Affiliations
                [1 ]GRID grid.469433.f, ISNI 0000 0004 0514 7845, Clinic for Nuclear Medicine and Competence Centre for Thyroid Diseases, Imaging Institute of Southern Switzerland, , Ente Ospedaliero Cantonale, ; Via A. Gallino 12, 6500 Bellinzona, Switzerland
                [2 ]GRID grid.7400.3, ISNI 0000 0004 1937 0650, Clinic for Nuclear Medicine, , University Hospital and University of Zurich, ; Zürich, Switzerland
                [3 ]GRID grid.10438.3e, ISNI 0000 0001 2178 8421, Unit of Endocrinology, Department of Clinical and Experimental Medicine, , University of Messina, ; Messina, Italy
                [4 ]GRID grid.412688.1, ISNI 0000 0004 0397 9648, Department of Oncology and Nuclear Medicine, , University Hospital Center “Sestre Milosrdnice”, ; Zagreb, Croatia
                [5 ]GRID grid.10438.3e, ISNI 0000 0001 2178 8421, Unit of Nuclear Medicine, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, , University of Messina, ; Messina, Italy
                [6 ]GRID grid.9851.5, ISNI 0000 0001 2165 4204, Faculty of Biology and Medicine, , University of Lausanne, ; Lausanne, Switzerland
                [7 ]GRID grid.469433.f, ISNI 0000 0004 0514 7845, Academic Education, Research and Innovation Area, , Ente Ospedaliero Cantonale, ; Bellinzona, Switzerland
                [8 ]GRID grid.29078.34, ISNI 0000 0001 2203 2861, Faculty of Biomedical Sciences, , Università della Svizzera italiana, ; Lugano, Switzerland
                [9 ]GRID grid.7605.4, ISNI 0000 0001 2336 6580, Nuclear Medicine Division, Department of Medical Sciences, AOU Città della Salute e della Scienza, , University of Turin, ; Turin, Italy
                Author information
                http://orcid.org/0000-0003-0230-0974
                Article
                419
                10.1007/s40336-021-00419-y
                7950424
                33728279
                93354f69-1fcb-481d-8eed-a4837003339d
                © Italian Association of Nuclear Medicine and Molecular Imaging 2021

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 17 January 2021
                : 25 February 2021
                Categories
                Systematic Review

                covid-19,sars-cov-2,thyroid,tsh,thyroid dysfunction,systematic review

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