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      Urinary Excretion of Podocalyxin Indicates Glomerular Epithelial Cell Injuries in Glomerulonephritis

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          Abstract

          Immunofluorescent study of urine sediments was performed to detect glomerular epithelial cell injuries using specific monoclonal antibody against podocalyxin, a glycoprotein that is prominently expressed on glomerular epithelial cells. Three kinds of structures (casts, granules and cells) were stained in urine sediments from various glomerular diseases. The presence of podocalyxin in urines was confirmed by absorption test, immunoelectron microscopy and Western blotting. Podocalyxin was detected in the urinary sediments of patients with various forms of glomerulonephritis, particularly those with acute onset. The amount of their urinary excretion apparently indicates the degree of the glomerular epithelial cell injuries in glomerular diseases.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1995
          1995
          17 December 2008
          : 69
          : 4
          : 397-403
          Affiliations
          aDepartment of Pediatrics, Yoshida Hospital, and bDepartment of Pathology, Institute of Nephrology, School of Medicine, Niigata University, Niigata, Japan
          Article
          188509 Nephron 1995;69:397–403
          10.1159/000188509
          7777103
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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