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      The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.

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          Abstract

          Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the whole body, tissue, cellular, and subcellular levels by a number of proteins, with zinc transporters being particularly important. In metazoan, two zinc transporter families, Zn transporters (ZnT) and Zrt-, Irt-related proteins (ZIP) function in zinc mobilization of influx, efflux, and compartmentalization/sequestration across biological membranes. During the last two decades, significant progress has been made in understanding the molecular properties, expression, regulation, and cellular and physiological roles of ZnT and ZIP transporters, which underpin the multifarious functions of zinc. Moreover, growing evidence indicates that malfunctioning zinc homeostasis due to zinc transporter dysfunction results in the onset and progression of a variety of diseases. This review summarizes current progress in our understanding of each ZnT and ZIP transporter from the perspective of zinc physiology and pathogenesis, discussing challenging issues in their structure and zinc transport mechanisms.

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          Author and article information

          Journal
          Physiol. Rev.
          Physiological reviews
          1522-1210
          0031-9333
          Jul 2015
          : 95
          : 3
          Affiliations
          [1 ] Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
          Article
          95/3/749
          10.1152/physrev.00035.2014
          26084690
          933f817f-39c1-4cd1-888c-f47ba3fa61cd
          Copyright © 2015 the American Physiological Society.
          History

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