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      Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma.

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          Abstract

          Infantile hemangiomas are the most common benign childhood tumor that may have functional and/or cosmetic complications. We aimed to compare the clinical efficacy of propranolol alone and propranolol primed with systemic corticosteroids on the outcome of infantile hemangioma. A prospective randomized study included 40 infants aged less than 9 months with cutaneous hemangiomas. Patients were randomly assigned into two groups: group A were given oral prednisolone for the initial 2 weeks combined with oral propranolol, while group B were given oral propranolol alone for 6 months. The median age of the studied patients was 4.5 months (ranged 4 weeks-8 months). Sequential determination of the dimensions of the hemangiomas based on direct measurement and photographic analysis were performed. A significant reduction in the size of the lesions was found in group A in the 2-, 4-, and 8-week evaluation compared to group B (p < 0.001) with no statistical difference in the ultimate 6 month response (p = 0.134). Multiple logistic regression showed that early treatment before 6 months of age (OR 9.82, p = 0.007) and combined treatment with propranolol and prednisolone (OR 10.71, p = 0.006) were the predictors of best response.

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          Author and article information

          Journal
          Eur. J. Pediatr.
          European journal of pediatrics
          Springer Nature America, Inc
          1432-1076
          0340-6199
          Nov 2015
          : 174
          : 11
          Affiliations
          [1 ] Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. dr_medodahab@hotmail.com.
          [2 ] Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. alaa_hamza@msn.com.
          [3 ] Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. heshamabdelkader@yahoo.com.
          [4 ] Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. hatemsaafan@yahoo.com.
          [5 ] Radiodiagnosis Department, Ain Shams University, Cairo, Egypt. mohamedshakerghazy@yahoo.com.
          [6 ] Hematology-Oncology Unit, Pediatric Department, Ain Shams University, Abbasseya Square, Cairo, Egypt. hragab68@hotmail.com.
          Article
          10.1007/s00431-015-2561-1
          10.1007/s00431-015-2561-1
          25982338

          Propranolol, Combined treatment, Infantile hemangioma

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