Nathalie Percie du Sert:
ORCID: http://orcid.org/0000-0002-9478-0540
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Viki Hurst: Role: Data curationRole: InvestigationRole: MethodologyRole: Project administrationRole:
ResourcesRole: Writing – original draft
Amrita Ahluwalia:
ORCID: http://orcid.org/0000-0001-7626-6399
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Sabina Alam:
ORCID: http://orcid.org/0000-0002-8615-9658
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Marc T. Avey:
ORCID: http://orcid.org/0000-0002-8696-3232
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Monya Baker: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
William J. Browne:
ORCID: http://orcid.org/0000-0002-6659-6885
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Alejandra Clark:
ORCID: http://orcid.org/0000-0002-1292-0408
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Innes C. Cuthill:
ORCID: http://orcid.org/0000-0002-5007-8856
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Ulrich Dirnagl:
ORCID: http://orcid.org/0000-0003-0755-6119
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Michael Emerson: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Paul Garner:
ORCID: http://orcid.org/0000-0002-0607-6941
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Stephen T. Holgate: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
David W. Howells:
ORCID: http://orcid.org/0000-0002-2512-7724
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Natasha A. Karp:
ORCID: http://orcid.org/0000-0002-8404-2907
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Stanley E. Lazic: Role: Writing – review & editing
Katie Lidster: Role: InvestigationRole: Project administrationRole: Writing – review & editing
Catriona J. MacCallum:
ORCID: http://orcid.org/0000-0001-9623-2225
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Malcolm Macleod:
ORCID: http://orcid.org/0000-0001-9187-9839
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Esther J. Pearl:
ORCID: http://orcid.org/0000-0001-6510-0959
Role: Writing – review & editing
Ole H. Petersen:
ORCID: http://orcid.org/0000-0002-6998-0380
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Frances Rawle:
ORCID: http://orcid.org/0000-0002-8877-6262
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Penny Reynolds:
ORCID: http://orcid.org/0000-0001-7480-6275
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Kieron Rooney:
ORCID: http://orcid.org/0000-0001-6563-7617
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Emily S. Sena:
ORCID: http://orcid.org/0000-0002-3282-8502
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Shai D. Silberberg: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Thomas Steckler:
ORCID: http://orcid.org/0000-0002-9927-5121
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Hanno Würbel:
ORCID: http://orcid.org/0000-0002-2934-3010
Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Isabelle Boutron: Role: Academic Editor
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Journal ID (pmc): plosbiol
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
14
July
2020
Publication date Collection:
July
2020
Publication date PMC-release: 14
July
2020
Volume: 18
Issue: 7
Electronic Location Identifier: e3000410
Affiliations
[1
]
NC3Rs, London, United Kingdom
[2
]
The William Harvey Research Institute, London, United Kingdom
[3
]
Barts Cardiovascular CTU, Queen Mary University of London, London, United Kingdom
[4
]
Taylor & Francis Group, London, United Kingdom
[5
]
Health Science Practice, ICF, Durham, North Carolina, United States of America
[6
]
Nature, San Francisco, California, United States of America
[7
]
School of Education, University of Bristol, Bristol, United Kingdom
[8
]
PLOS ONE, Cambridge, United Kingdom
[9
]
School of Biological Sciences, University of Bristol, Bristol, United Kingdom
[10
]
QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department
of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany
[11
]
National Heart and Lung Institute, Imperial College London, London, United Kingdom
[12
]
Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool
School of Tropical Medicine, Liverpool, United Kingdom
[13
]
Clinical and Experimental Sciences, University of Southampton, Southampton, United
Kingdom
[14
]
Tasmanian School of Medicine, University of Tasmania, Hobart, Australia
[15
]
Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge,
United Kingdom
[16
]
Prioris.ai Inc, Ottawa, Canada
[17
]
Hindawi Ltd, London, United Kingdom
[18
]
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
[19
]
Academia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom
[20
]
Medical Research Council, London, United Kingdom
[21
]
Statistics in Anesthesiology Research (STAR) Core, Department of Anesthesiology, College
of Medicine, University of Florida, Gainesville, Florida, United States of America
[22
]
Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University
of Sydney, Sydney, Australia
[23
]
National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United
States of America
[24
]
Janssen Pharmaceutica NV, Beerse, Belgium
[25
]
Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland
University Paris Descartes, FRANCE
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: AA is the editor in chief of the British Journal of Pharmacology.
WJB, ICC, and ME are authors of the original ARRIVE guidelines. WJB serves on the
Independent Statistical Standing Committee of the funder CHDI foundation. AC is a
Senior Editor for PLOS ONE. AC, CJM, MM, and ESS were involved in the IICARus trial.
ME, MM, and ESS have received funding from NC3Rs. ME sits on the MRC ERPIC panel.
STH is chair of the NC3Rs board; trusteeship of the BLF, Kennedy Trust, DSRU, and
CRUK; member of Governing Board, Nuffield Council of Bioethics, member Science Panel
for Health (EU H2020); founder and NEB Director Synairgen; consultant Novartis, Teva,
and AZ; and chair MRC/GSK EMINENT Collaboration. VH, KL, EJP, and NPdS are NC3Rs staff;
role includes promoting the ARRIVE guidelines. SEL and UD are on the advisory board
of the UK Reproducibility Network. CJM has shareholdings in Hindawi, is on the publishing
board of the Royal Society, and on the EU Open Science policy platform. UD, MM, NPdS,
CJM, ESS, TS, and HW are members of EQIPD. MM is a member of the Animals in Science
Committee and on the steering group of the UK Reproducibility Network. NPdS and TS
are associate editors of BMJ Open Science. OHP is vice president of Academia Europaea,
editor in chief of Function, senior executive editor of the Journal of Physiology,
and member of the Board of the European Commission’s SAPEA (Science Advice for Policy
by European Academies). FR is an NC3Rs board member and has shareholdings in GSK.
FR and NAK have shareholdings in AstraZeneca. PR is a member of the University of
Florida Institutional Animal Care and Use Committee and editorial board member of
Shock. ESS is editor in chief of BMJ Open Science. SDS’s role is to provide expertise
and does not represent the opinion of the NIH. TS has shareholdings in Johnson & Johnson.
SA, MTA, MB, PG, DWH, and KR declared no conflict of interest.
Author information
Article
Publisher ID:
PBIOLOGY-D-19-01863
DOI: 10.1371/journal.pbio.3000410
PMC ID: 7360023
PubMed ID: 32663219
SO-VID: 9364ca72-7174-4f17-b6df-fdd82b04f0a5
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
Funded by: funder-id http://dx.doi.org/10.13039/501100000849, National Centre for the Replacement, Refinement and Reduction of Animals in Research;
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9478-0540
Nathalie Percie du Sert
This work was supported by the National Centre of the Replacement, Refinement and
Reduction on Animals in Research (NC3Rs,
https://www.nc3rs.org.uk/). NPdS, KL, VH, and EJP are employees of the NC3Rs.
Subject:
Perspective
Subject:
Research and Analysis Methods
Subject:
Research Assessment
Subject:
Research Reporting Guidelines
Subject:
Research and Analysis Methods
Subject:
Research Assessment
Subject:
Reproducibility
Subject:
Research and Analysis Methods
Subject:
Research Design
Subject:
Research and Analysis Methods
Subject:
Research Assessment
Subject:
Research Validity
Subject:
Science Policy
Subject:
Research and Analysis Methods
Subject:
Research Design
Subject:
Experimental Design
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Research and Analysis Methods
Subject:
Research Facilities
Subject:
Research Laboratories
