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      Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

      , , , ,
      Immunity
      Elsevier BV

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          Abstract

          Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits proliferation in vitro, IFN I-induced proliferation of CD8+ cells in vivo presumably occurs indirectly through production of secondary cytokines, e.g., interleukin-2 (IL-2) or IL-15. We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong and selective stimulation of memory-phenotype CD44hi CD8+ (but not CD4+) cells in vivo; similar specificity applies to purified T cells in vitro and correlates with much higher expression of IL-2Rbeta on CD8+ cells than on CD4+ cells.

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          Author and article information

          Journal
          Immunity
          Immunity
          Elsevier BV
          10747613
          May 1998
          May 1998
          : 8
          : 5
          : 591-599
          Article
          10.1016/S1074-7613(00)80564-6
          9620680
          9368d37e-5e86-40ea-afa0-6a17aceee7fa
          © 1998

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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