Effects of Rhubarb Tannins on Uremic Toxins

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Abstract

The effects of each of several tannins purified from Rhei Rhizoma on serum constituents were investigated in rats with adenine-induced renal failure. Blood levels of urea nitrogen, methylguanidine (MG), and guanidinosuccinic acid (GSA) were significantly decreased in rats given ( – )-epicatechin 3-O-gallate at a dose of 2.5, 5, or 10 mg/kg body weight/day for 24 days. The creatinine (Cr) level was also significantly decreased in rats given 5 and 10 mg of this compound. A significant decrease in urea nitrogen, MG, and GSA was found in rats given 6.25 mg procyanidin B-2 3,3’-di-O-gallate. However, unlike the former two components, the administration of 12.5 mg of procyanidin C-1 3,3’,3”-tri-O-gallate produced a considerable or significant increase in blood levels of urea nitrogen, Cr, MG, and GSA. RG-tannin had a weaker overall effect on serum constituents except for GSA in comparison with the corresponding effect of ( – )-epicatechin 3-O-gallate and 6.25 mg of procyanidin B-2 3,3’-di-O-gallate. Rhatannin tended to increase the serum nitrogen constituents.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1991

Publication date (Print): 1991

Publication date (Electronic): 11 December 2008

Volume: 58

Issue: 2

Pages: 155-160

Affiliations

^aDepartment of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University; ^bFaculty of Pharmaceutical Sciences, Kyushu University, Japan

Article

Publisher ID: 186406 Other ID: Nephron 1991;58:155–160

DOI: 10.1159/000186406

PubMed ID: 1865970

SO-VID: 937dfec2-ab87-4b00-a132-769123130dd2

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 25 July 1990

Page count

Pages: 6

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