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      Effects of Rhubarb Tannins on Uremic Toxins

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          Abstract

          The effects of each of several tannins purified from Rhei Rhizoma on serum constituents were investigated in rats with adenine-induced renal failure. Blood levels of urea nitrogen, methylguanidine (MG), and guanidinosuccinic acid (GSA) were significantly decreased in rats given ( – )-epicatechin 3-O-gallate at a dose of 2.5, 5, or 10 mg/kg body weight/day for 24 days. The creatinine (Cr) level was also significantly decreased in rats given 5 and 10 mg of this compound. A significant decrease in urea nitrogen, MG, and GSA was found in rats given 6.25 mg procyanidin B-2 3,3’-di-O-gallate. However, unlike the former two components, the administration of 12.5 mg of procyanidin C-1 3,3’,3”-tri-O-gallate produced a considerable or significant increase in blood levels of urea nitrogen, Cr, MG, and GSA. RG-tannin had a weaker overall effect on serum constituents except for GSA in comparison with the corresponding effect of ( – )-epicatechin 3-O-gallate and 6.25 mg of procyanidin B-2 3,3’-di-O-gallate. Rhatannin tended to increase the serum nitrogen constituents.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1991
          1991
          11 December 2008
          : 58
          : 2
          : 155-160
          Affiliations
          aDepartment of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University; bFaculty of Pharmaceutical Sciences, Kyushu University, Japan
          Article
          186406 Nephron 1991;58:155–160
          10.1159/000186406
          1865970
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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