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      A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man :

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      Pain

      Elsevier BV

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          Most cited references 23

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          Ethical guidelines for investigations of experimental pain in conscious animals

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            Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa.

            (1) When hindlimb peripheral nerves are cut across in rats and mice, there is a tendency for the animal to attack the anaesthetic limb. We have called this attack "autotomy". In this paper we describe the time course and degree of autotomy following various types of nerve injury. (2) Four different types of lesion were applied to the sciatic nerve of rats. The most serious autotomy was produced by section of the nerve and encapsulation of its cut end in a polythene tube. Section followed by immediate resuturing also produced serious autotomy. Simple ligation of the nerve end was followed by less autotomy than encapsulation or cut and resuture. A crush lesion caused only minimal attack. (3) Section of the saphenous branch of the femoral nerve produced no autotomy. However, if the saphenous and sciatic nerves were ligated at the same time so that the entire foot became anaesthetic there was a great increase of autotomy over that seen when the sciatic nerve alone was ligated. This increase with the double lesion occurred even if the saphenous nerve was ligated more than 100 days after the sciatic nerve had been cut. (4) Mice showed autotomy very similar to that seen in rats but the onset was somewhat faster. (5) Reasons are given to propose that autotomy is triggered by an abnormal afferent barrage generated in the cut end of the nerve. Autotomy from peripheral nerve lesions is a different phenomenon from that seen after dorsal root section. Autotomy occurs under conditions which produce anaesthesia dolorosa in man. This simple model may be suitable for studies of the prevention of irritations originating from chronic lesions of peripheral nerves.
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              Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma.

               P. Wall,  M Gutnick (1974)
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                Author and article information

                Journal
                Pain
                Pain
                Elsevier BV
                0304-3959
                1988
                April 1988
                : 33
                : 1
                : 87-107
                Article
                10.1016/0304-3959(88)90209-6
                © 1988

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