14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Adenoviruses in immunocompromised hosts.

      1
      Clinical microbiology reviews
      American Society for Microbiology

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The number of patients with acquired immunodeficiency has grown steadily as a result of both a larger number of patients receiving solid organ and hematopoietic stem cell transplants and their longer survival times. The use of newer, more potent immunosuppressive regimens has increased the frequency of severe adenovirus infections. Human adenoviruses are a large group of viruses, represented by at least 52 serotypes with various genotypes divided into genomic clusters, and these may cause a broad variety of clinical manifestations. The development of molecular methods has increased the sensitivity and rapidity of adenovirus infection diagnosis. The implementation of PCR assays has significantly contributed to the identification of patients with disseminated adenovirus disease. More recently, the development of real-time PCR assays has permitted virus quantification and patient follow-up. There is no treatment for adenovirus with demonstrated efficacy, although cidofovir is widely used. Sensitive diagnostic tests for adenovirus can contribute to the early diagnosis and successful treatment of life-threatening adenovirus infections, especially in complex immunocompromised patients. The development of improved adenovirus therapy still remains a challenge. Adenovirus genetic diversity should be considered for diagnosis, typing, and therapeutic interventions.

          Related collections

          Author and article information

          Journal
          Clin Microbiol Rev
          Clinical microbiology reviews
          American Society for Microbiology
          1098-6618
          0893-8512
          Oct 2008
          : 21
          : 4
          Affiliations
          [1 ] Clinical Virology Laboratory, Centro de Educación Médica e Investigaciones Clínicas, University Hospital, Galvan, Buenos Aires, Argentina. mechavarria@cemic.edu.ar
          Article
          21/4/704
          10.1128/CMR.00052-07
          2570151
          18854488
          9385c052-e4fc-4ef8-bb85-73e7bac0bc8d
          History

          Comments

          Comment on this article